2010 Fiscal Year Final Research Report
Studies on the biological effects and mode of action of pollutants in marine animals
| Project/Area Number |
20510060
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation/Chemicals
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
AZUMI Kaoru Hokkaido University, 環境健康科学研究教育センター, 特任講師 (90221720)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 海産動物 / 無脊椎動物 / ホヤ / DNAマイクロアレイ / 遺伝子発現 / 有機スズ / 重金属 / 内分泌撹乱物質 |
|---|
| Research Abstract |
We obtained gene expression profile data from ascidians after exposure to organotin compounds, metal ions, or endocrine disruptors for 72h. We then categorized the up- or down-regulated genes for each pollutant using our classification method, and estimated the biological effects of each pollutant. We developed high-throughput methods for screening embryogenesis and metamorphosis using ascidian eggs and larva, and analyzed the inhibitory effects of each pollutant. Furthermore, we found nine marker genes for monitoring environmental contamination due to organotins.
|
