2010 Fiscal Year Final Research Report
Validation system of chemicals using BAC vector transfected ES cells
| Project/Area Number |
20510063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
TAKADA Tatsuyuki Ritsumeikan University, 薬学部, 教授 (90206756)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Yoshinori 名城大学, 薬学部, 助教 (50512323)
NOCE Toshiaki 滋賀医科大学, 動物生命科学研究センター, 特任教授 (70183902)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 内分泌撹乱物質 / ES細胞 / 細胞分化 / 生殖細胞分化 |
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| Research Abstract |
Germ cell related gene which expression was up-regulated by the exposure to bisphenol A(BPA) was identified. ES cell line which express venus under the control of this promoter was established. This ES cell line express venus in the presence of chemicals in a dose-dependent manner, suggesting validation system of environmental chemicals can be achieved using reporter ES cells.
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[Journal Article] Anti-breast cancer potential of SS1020, a novel antiestrogen lacking estrogenic and genotoxic actions2010
Author(s)
Laxmi YR, Liu X, Suzuki N, Kim SY, Okamoto K, Kim HJ, Zhang G, Chen JJ, Okamoto Y, Shibutani S.
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Journal Title
Int J Cancer 127
Pages: 1718-26
Peer Reviewed
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[Journal Article] Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression and consequent hypertriglyceridaemia.2009
Author(s)
Ugi, S., Shi, K., Nishio, Y., Shimizu, S., Guo, B., Sekine, O., Ikeda, K., Egawa, K., Yoshizaki, T., Nagai, Y., Koya, D., Takada, T., Torii, R., Kimura, H., Kashiwagi, A., Maegawa, H.
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Journal Title
J.Biochem. 146
Pages: 541-547
Peer Reviewed
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