2010 Fiscal Year Final Research Report
OMICS ANALYSIS TO INVESTIGATE ROLES OF MICRORNAS IN CANCER
| Project/Area Number |
20510184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUKUOKA Yutaka Tokyo Medical and Dental University, 大学院・疾患生命科学研究部, 准教授 (30242217)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUSHIMA Hiroshi 東京医科歯科大学, 大学院・疾患生命科学研究部, 特任教授 (50219630)
TANAKA Hiroshi 東京医科歯科大学, 大学院・疾患生命科学研究部, 教授 (60155158)
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| Co-Investigator(Renkei-kenkyūsha) |
INAOKA Hidenori 北里大学, 医療衛生学部, 講師 (30282768)
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| Project Period (FY) |
2008 – 2010
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| Keywords | システムゲノム / がん / マイクロRNA / 遺伝子 / 発現 / マイクロアレイ |
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| Research Abstract |
To investigate the local effect of miRNA in cancer, we analyzed gene and miRNA expressions in hepatocellular carcinoma (HCC) and surrounding non-tumor tissues. We calculated the Pearson correlation coefficients between miRNAs neighboring genes and compared the coefficients in the tumor and non-tumor tissues. This analysis was repeated for intronic and intergenic miRNAs. Finally, the correlation coefficients between miRNAs and their target genes were compared in the tumor and non-tumor tissues. The results suggested that in HCC, more miRNAs correlated with neighboring genes positively and that the correlation coefficients between the intronic miRNAs and their host genes were higher in HCC. The correlation analysis between miRNAs and their targets suggested that there was no significant difference between the correlation coefficients in the tumor and non-tumor tissues.
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[Journal Article] Up-regulation of PSF1 promotes the growth of breast cancer cells2010
Author(s)
Nakahara I, Miyamoto M, Shibata T, Akashi-Tanaka S, Kinoshita T, Mogushi K, Oda K, Ueno M, Takakura N, Mizushima H, Tanaka H, Ohta T
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Journal Title
Genes Cells 15
Pages: 1015-1024
Peer Reviewed
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[Journal Article] Clinical omics analysis of colorectal cancer incorporating copy number aberrations and gene expression data2010
Author(s)
Yoshida T, Kobayashi T, Itoda M, Muto T, Miyaguchi K, Mogushi K, Shoji S, Shimokawa K, Iida S, Uetake H, Ishikawa T, Sugihara K, Mizushima H, Tanaka H
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Journal Title
Cancer Inform 29
Pages: 147-161
Peer Reviewed
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[Journal Article] The phenotype and genotype experiment object model (PaGE-OM) : a robust data structure for information related to DNA variation2009
Author(s)
Brookes AJ, Lehvaslaiho H, Muilu J, Shigemoto Y, Oroguchi T, Tomiki T, Mukaiyama A, Konagaya A, Kojima T, Inoue I, Kuroda M, Mizushima H, Thorisson GA, Dash D, Rajeevan H, Darlison MW, Woon M, Fredman D, Smith AV, Senger M, Naito K, Sugawara H
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Journal Title
Hum Mutat 30
Pages: 968-977
Peer Reviewed
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[Journal Article] Expression of Aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue2009
Author(s)
Yasen M, Mizushima H, Mogushi K, Obulhasim G, Miyaguchi K, Inoue K, Nakahara I, Ohta T, Aihara A, Tanaka S, Arii S, Tanaka H
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Journal Title
Cancer Sci 100
Pages: 472-480
Peer Reviewed
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