2010 Fiscal Year Final Research Report
Functional analysis of the enzymes involved in the structural modification of polyketides and its application to the production of novel scaffolds
| Project/Area Number |
20510205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Musashino University |
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Principal Investigator |
ICHINOSE Koji Musashino University, 薬学研究所, 教授 (40282610)
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| Co-Investigator(Kenkyū-buntansha) |
TAGUCHI Takaaki 武蔵野大学, 薬学研究所, 講師 (80409383)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 抗生物質 / 生合成 / 放線菌 |
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| Research Abstract |
One of the key factors for medicinal developments is the structural diversity in the lead compounds. Our research has focused on the actinomycete bacteria, which produce most of the clinically important antibiotics, to reveal the function of a key biosynthetic enzyme leading to structural diversity. In this project, we characterized an oxygenase, ActVA-5/ActVB, for the actinorhodin biosynthesis in Streptomyces coelicolor A3 (2), to discover its quinine-forming activity, together with an additional enzymatic function as epoxyquinone formation.
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