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2010 Fiscal Year Final Research Report

Functional analysis of the enzymes involved in the structural modification of polyketides and its application to the production of novel scaffolds

Research Project

  • PDF
Project/Area Number 20510205
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionMusashino University

Principal Investigator

ICHINOSE Koji  Musashino University, 薬学研究所, 教授 (40282610)

Co-Investigator(Kenkyū-buntansha) TAGUCHI Takaaki  武蔵野大学, 薬学研究所, 講師 (80409383)
Project Period (FY) 2008 – 2010
Keywords抗生物質 / 生合成 / 放線菌
Research Abstract

One of the key factors for medicinal developments is the structural diversity in the lead compounds. Our research has focused on the actinomycete bacteria, which produce most of the clinically important antibiotics, to reveal the function of a key biosynthetic enzyme leading to structural diversity. In this project, we characterized an oxygenase, ActVA-5/ActVB, for the actinorhodin biosynthesis in Streptomyces coelicolor A3 (2), to discover its quinine-forming activity, together with an additional enzymatic function as epoxyquinone formation.

  • Research Products

    (9 results)

All 2010 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Practical procedures for genetic manipulation systems for medermycin-producing Streptomyces sp.AM-7161.2010

    • Author(s)
      Huiqun Deng, Xiaofeng Cai, Jianxin Peng, Huazhu Hong, Koji Ichinose, Aiying Li
    • Journal Title

      J.Basic Microbiol. 50

      Pages: 299-301

    • Peer Reviewed
  • [Journal Article] Biosynthesis of Actinorhodin and Related Antibiotics : Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster.2009

    • Author(s)
      Susumu Okamoto, Takaaki Taguchi, Kozo Ochi, Koji Ichinose
    • Journal Title

      Chem.Biol. 16

      Pages: 226-236

    • Peer Reviewed
  • [Presentation] Actinorhodin及びalunumycinの生合成に関わる二成分系モノオキシゲナーゼの機能解析2010

    • Author(s)
      田口貴章
    • Organizer
      日本放線菌学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-03
  • [Presentation] アクチノロジン生合成におけるモノオキシゲナーゼ酵素系ActVA-5/ActVBのエポキシ化活性の発見と解析2010

    • Author(s)
      田口貴章
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
  • [Presentation] Discovery of alternative routes for actinorhodin quinone formation2009

    • Author(s)
      田口貴章
    • Organizer
      15th International Symposium on the Biology of Actinomycetes (ISBA15)
    • Place of Presentation
      Shanghai, PRC
    • Year and Date
      2009-08-21
  • [Presentation] Actinorhodin生合成に関わるActVA-5/ActVB酵素系のモノオキシゲナーゼ活性の検討2009

    • Author(s)
      田口貴章
    • Organizer
      日本放線菌学会2009年度大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-07-16
  • [Presentation] Actinorhodin生合成後期修飾過程における酸素導入に関する新たな知見2008

    • Author(s)
      田口貴章
    • Organizer
      第50回天然有機化合物討論会
    • Place of Presentation
      福岡
    • Year and Date
      2008-09-30
  • [Presentation] Actinorhodin生合成におけるActVA-5,ActVA-6の機能解析2008

    • Author(s)
      田口貴章
    • Organizer
      日本放線菌学会2008年度大会
    • Place of Presentation
      山梨
    • Year and Date
      2008-07-11
  • [Remarks] ホームページ等

    • URL

      http://www.musashino-u.ac.jp/yakugaku/shoyakukagaku/

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Published: 2012-01-26   Modified: 2016-04-21  

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