2011 Fiscal Year Final Research Report
Role of pro-peptide region as an intra-molecular chaperone and its application
| Project/Area Number |
20510207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Kinki University |
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Principal Investigator |
HIDAKA Yuji 近畿大学, 理工学部, 教授 (70212165)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Hiroshi 関西学院大学, 理工学部, 教授 (10252719)
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| Project Period (FY) |
2008 – 2011
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| Keywords | フォールディング / 生理活性ペプチド / プロペプチド / 前駆体 / ウログアニリン / グアニル酸シクラーゼ / 構造生物学 / 結晶構造 |
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| Research Abstract |
Role of propeptide-region of peptide hormone as an intra-molecular chaperone was investigated to elucidate structure-function relationship of peptide hormone during its development. Folding and X-ray structural analyses of prourogunaylin revealed that intra-molecular chaperon plays a critical role for the maintenance of the local stability of the biologically active site related to the net stabilization of the precursor molecule during its development.
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