2010 Fiscal Year Final Research Report
Behavioral deficits in rats treated neonatally with an NMDA antagonist, a putative animal model of schizophrenia
| Project/Area Number |
20530664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Osaka City University |
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Principal Investigator |
KAWABE Kouichi Osaka City University, 大学院・文学研究科, 准教授 (30336797)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 作業記憶 / sensorimotor gating / NMDA受容体 / グルタミン酸神経系 / 認知障害 / 統合失調症 / 動物モデル / 生理心理学 |
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| Research Abstract |
Rats treated neonatally with an NMDA antagonist (MK-801), which are supposed as a putative animal model of schizophrenia, were tested for behavioral or cognitive deficits. Rats were treated with MK-801 from postnatal days 7 to 20. Sensorimotor gating and working memory was tested in adulthood, using prepulse inhibition (PPI) and spontaneous alternation (SA), respectively. As results, MK-801 induced a marginally significant impairment in PPI, but not in SA. MK-801 treatment in a short period (5 days) did not have any behavioral effects.
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Research Products
(6 results)
