2010 Fiscal Year Final Research Report
A study on the molecular mechanisms of the functions of a peptide-gated Na^+ channel
| Project/Area Number |
20570071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Hiroshima University |
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Principal Investigator |
FURUKAWA Yasuo Hiroshima University, 大学院・総合科学研究科, 教授 (40209169)
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| Project Period (FY) |
2008 – 2010
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| Keywords | イオンチャネル / ペプチド / 構造機能相関 |
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| Research Abstract |
Molecular aspects of the functions of a peptide-gated Na+ channel, FMRFamide-gated Na+ channel (FaNaC), were examined in this study. We found that the position 552 of FaNaC is involved in the activation and the desensitization of the channel, and that the negative electric charge on this position (Asp552) is essential for the inward rectification of the channel current.
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