2010 Fiscal Year Final Research Report
Study on the prolactin receptors and there signal transduction in fish erythrophores and xanthophores.
| Project/Area Number |
20570076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Toho University |
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Principal Investigator |
OSHIMA Noriko Toho University, 理学部, 教授 (70057735)
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| Co-Investigator(Kenkyū-buntansha) |
IWAMURO Showichi 東邦大学, 理学部, 准教授 (70221794)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 赤色素胞 / 黄色素胞 / プロラクチン受容体 / シグナル伝達 |
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| Research Abstract |
We found that a pituitary hormone, prolactin (PRL), causes pigment dispersion in fish erythrophores and xanthophores. In the present study, therefore, cloning of PRL receptors in these chromatophores was performed and the receptors were identified as PRLR1 type. It was also suggested that the pigment dispersion by PRL is revealed through a novel signaling pathway, PRLR-Jak2-Grb2-Ras-adenylate cyclase (AC)-PKA pathway.
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