2010 Fiscal Year Final Research Report
Study for degradation mechanism of a cell cycle regulator induced by Stress-activated MAP kinases
| Project/Area Number |
20570126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
UCHIDA Sanae Kanazawa University, イノベーション創成センター, 博士研究員 (50464045)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Katsumi 金沢大学, 薬学系, 准教授 (10191280)
KUDO Yasusei 広島大学, 医歯(薬)学総合研究科, 助教 (50314753)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ストレス / シグナル伝達 / 細胞周期 / 蛋白分解 |
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| Research Abstract |
We previously found that non-genotoxic stress, whose primary target is not genomic DNA, induced cell cycle arrest through the degradation of Cdc25A and Cdc25B. In this study, we discovered that Cdc25B was degraded through the ubiquitylation by SCF^<βTrCP> induced by the phosphorylation of Ser101/103 by stress-activated MAP kinases.
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