2010 Fiscal Year Final Research Report
Functions of telomere in chromosome segregation
| Project/Area Number |
20570165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Osaka University (2009-2010)
Kyoto University (2008) |
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Principal Investigator |
KANOH Junko 大阪大学, 蛋白質研究所, 特任准教授 (10323809)
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| Project Period (FY) |
2008 – 2010
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| Keywords | テロメア / 細胞分裂 / 染色体 |
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| Research Abstract |
To investigate the functions of telomere in mitosis, we analyzed the regulatory mechanisms of telomere in fission yeast, which undergoes closed mitosis without the nuclear envelope breakdown. Fission yeast telomeres were anchored to the NE in interphase, whereas they were transiently released from the NE in M phase, which was important for the chromosome stability. Furthermore, the Rap1 protein, one of the central telomere proteins, was phosphorylated in mitosis, which induced the detachment of Rap1 from a nuclear membrane protein Bqt4. We proposed the model that the detachment of telomeres from the NE is a common mechanism for both closed and open mitoses.
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[Journal Article] A conserved motif within RAP1 plays diversified roles in telomere protection and regulation in different organisms2011
Author(s)
Chen, Y., Rai, R., Zhou, Z-R., Kanoh, J., Ribeyre, C., Yang, Y., Zheng, H., Damay, P., Wang, F., Tsujii, H., Hiraoka, Y., Shore, D., Hu, H-Y., Chang, S. and Lei, M.
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Journal Title
Nature Struct. Mol. Biol.
Volume: 18
Pages: 213-221
Peer Reviewed
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[Presentation] Roles of telomere in closed mitosis2011
Author(s)
Tsujii, H., Tanaka, M., Chikashige, Y., Watanabe, Y., Saito, M., Ishikawa, F., Hioraka, Y., and Kanoh, J.
Organizer
The sixth international fission yeast meeting
Place of Presentation
Boston, USA
Year and Date
2011-05-29
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[Presentation] Regulations of telomere at M phase2010
Author(s)
Tsujii, H., Chikashige, Y., Watanabe, Y., Saito, M., Ishikawa, F., Hiraoka, Y., and Kanoh, J.
Organizer
Telomeres and the DNA damage response
Place of Presentation
Marseille, France
Year and Date
2010-09-16
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[Presentation] Regulations of telomeres at M phase2009
Author(s)
Kanoh, J., Chikashige, Y., Watanabe, Y., Saito, M., Hiraoka, Y., and Ishikawa, F.
Organizer
The fifth international fission yeast meeting
Place of Presentation
Tokyo, Japan
Year and Date
2009-10-27
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