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2010 Fiscal Year Final Research Report

The role of membrane phospholipids in establishment of cell polarity

Research Project

  • PDF
Project/Area Number 20570174
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionHokkaido University

Principal Investigator

KAMADA Konomi  Hokkaido University, 遺伝子病制御研究所, 准教授 (80312354)

Project Period (FY) 2008 – 2010
Keywords細胞 / 脂質 / 極性形成
Research Abstract

In most eukaryotic cells, cell membranes are composed of two layers that have different composition of phospholipids. We have investigated molecular mechanisms and roles of translocation of phospholipids between two layers in yeast. We identified some novel factors involved in translocation of phospholipids in the plasma membrane and a membrane protein implicated in fluidity of the plasma membrane. Moreover, an F-box protein Rcy1 is suggested to function as a mediator between vesicle formation and translocation of phospholipids catalyzed by Drs2 in endosomes.

  • Research Products

    (12 results)

All 2011 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Isolation and characterization of novel mutations in CDC50, the non-catalytic subunit of the Drs2p phospholipid flippase2011

    • Author(s)
      Takahashi Y., Fujimura-Kamada K., Kondo S., Tanaka K.
    • Journal Title

      J.Biochem. 149

      Pages: 423-432

    • Peer Reviewed
  • [Journal Article] Functions of phospholipid flippases.2011

    • Author(s)
      Tanaka K., Fujimura-Kamada K., Yamamoto T.
    • Journal Title

      J Biochem. 149

      Pages: 131-143

    • Peer Reviewed
  • [Presentation] The functional analysis of phospholipid flippase in endocytic recycling.2010

    • Author(s)
      鎌田このみ、花松久寿、斉藤康二、塩路慧能、鈴木理紗、田中一馬
    • Organizer
      Sapporo International Cancer Symposium 2010 "Membrane Traffic and Cancer"
    • Place of Presentation
      北海道大学学術交流会館
    • Year and Date
      20100628-20100629
  • [Presentation] How is the plasma membrane phosphatidylserine (PS) asymmetry generated in Saccharomyces cerevisiae?2010

    • Author(s)
      三岡哲夫、鎌田このみ、田中一馬
    • Organizer
      BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会(合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
  • [Presentation] Yeast phospholipid translocase Drs2-Cdc50 functions with an F-box protein Rcy1 in endocytic recycling.2010

    • Author(s)
      花松久寿、鎌田このみ、田中一馬
    • Organizer
      BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会(合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-08
  • [Presentation] Regulation and functional significance of phospholipid asymmetry.2010

    • Author(s)
      田中一馬、鎌田このみ、山本隆晴
    • Organizer
      第27回内藤コンファレンス
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ
    • Year and Date
      2010-07-01
  • [Presentation] The functional analysis of phospholipid flippase in endocytic recycling.2010

    • Author(s)
      鎌田このみ、花松久寿、斉藤康二、塩路慧能、鈴木理紗、田中一馬
    • Organizer
      第27回内藤コンファレンス
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ
    • Year and Date
      2010-07-01
  • [Presentation] 膜脂質非対称性の制御機構と細胞機能2010

    • Author(s)
      田中一馬、鎌田このみ、山本隆晴
    • Organizer
      日本農芸化学会2010年度大会シンポジウム「微生物における脂質シグナリング」
    • Place of Presentation
      東京大学
    • Year and Date
      2010-03-30
  • [Presentation] Regulation of phospholipid asymmetry by flippases and their cell functions.2009

    • Author(s)
      田中一馬、鎌田このみ、山本隆晴
    • Organizer
      第82回日本生化学会大会シンポジウム「膜リン脂質トポロジーの生物学/Biology of phospholipid dynamics」
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-10-24
  • [Presentation] Cellular functions of phospholipid flippases.2009

    • Author(s)
      田中一馬、鎌田このみ、山本隆晴
    • Organizer
      The fourth iCeMS International Symposium
    • Place of Presentation
      ホテルフジタ京都
    • Year and Date
      2009-05-28
  • [Presentation] 脂質の膜脂質二重層間輸送が制御する細胞機能2008

    • Author(s)
      田中一馬、鎌田このみ、山本隆晴
    • Organizer
      第31回日本分子生物学会・第81生化学会大会・合同大会シンポジウム「モデル生物を用いた脂質生物学:様々な生物における膜脂質の多様な生物機能」
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-10
  • [Presentation] Roles of flippases in yeast endocytic recycling.2008

    • Author(s)
      田中一馬、鎌田このみ、山本隆晴
    • Organizer
      Flippase 2008
    • Place of Presentation
      Centro Stefano Francini, Monte Verita, Ascona, Switzerland
    • Year and Date
      2008-11-06

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Published: 2012-01-26   Modified: 2016-04-21  

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