2010 Fiscal Year Final Research Report
Analysis of RNA-binding proteins that regulate meiotic cell cycle in fission yeast
| Project/Area Number |
20570178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMASHITA Akira The University of Tokyo, 大学院・理学系研究科, 講師 (30312276)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細胞周期 / 減数分裂 / 発現制御 |
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| Research Abstract |
The aim of this study is to elucidate the function of RNA-binding proteins, Mei2p and Mmi1p, that regulate meiotic cell cycle in fission yeast. It turned out that phosphorylation of RNA polymerase II is crucial for the expression of Mei2p. It has been also proved that polyadenylation of meiotic mRNAs is essential for the selective elimination induced by Mmi1p.
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