2010 Fiscal Year Final Research Report
Approach to metabolic syndrome by analysing the energy metabolism homeostasis
| Project/Area Number |
20580103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Keio University |
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Principal Investigator |
WATANABE Mitsuhiro Keio University, 医学部, 准教授 (10450842)
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| Co-Investigator(Kenkyū-buntansha) |
TANIGAWARA Yusuke 慶應義塾大学, 医学部, 教授 (30179832)
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
MORIMOTO Kokichi 慶應義塾大学, 医学部, 助教 (10468506)
SUGIZAKI Taichi 慶應義塾大学, 医学部, 助教 (00468480)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 代謝 / 糖尿病 / 胆汁酸 / 核内受容体 |
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| Research Abstract |
Administration of FXR agonist accentuated body weight gain and glucose intolerance induced by the high fat diet and led to a pronounced worsening of the changes in liver and adipose tissue. Mechanistically, treatment with FXR agonist decreased BA biosynthesis, BA pool size and energy expenditure. Our data hence suggest that activation of FXR with synthetic agonists is not useful for long term management of the metabolic syndrome, as it reduces the BA pool size and subsequently decreases energy expenditure, translating in weight gain and insulin resistance. In addition, it was suggested that bile acid participated in amino acid metabolism in energy homeostasis by DNA micro array and metabolome analysis.
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[Journal Article] Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine.2011
Author(s)
Atsushi Tamura, Hisayoshi Hayashi, Mitsunobu Imasato, Yuji Yamazaki, Asuka Hagiwara, Masami Wada, Tetsuo Noda, Mitsuhiro Watanabe, Yuichi Suzuki, Sachiko Tsukita
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Journal Title
Gastroenterology. 140
Pages: 913-923
Peer Reviewed
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[Remarks] ホームページ等
