2010 Fiscal Year Final Research Report
Chemical Biology of lifespan-extending substrates secreted by the nematode Caenorhabditis elegans
| Project/Area Number |
20580112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tottori University |
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Principal Investigator |
KAWANO Tsuyoshi Tottori University, 農学部, 教授 (50270567)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 寿命 / 休眠 / インスリン / 線虫 / 発現制御 |
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| Research Abstract |
I have identified Caenorhabditis elegans insulin-like genes ins-6, ins-12, and ins-35. Expression of these genes was regulated by lifespan-extending substances secreted by C.elegans. Gene-disruption revealed that ins-6 and ins-12 were relevant to regulation of lifespan. In contrast, ins-35 was largely relevant to regulation of larval diapause not adult lifespan. In addition, analyses of expression patterns of ins-35 allowed me to understand the physiological function of the gene.
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