2010 Fiscal Year Final Research Report
Study on the mechanisms by which functional foods regulate androgen receptor function
| Project/Area Number |
20580141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
YAMAJI Ryoichi Osaka Prefecture University, 生命環境科学研究科, 准教授 (00244666)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アンドロゲン / アンドロゲン受容体 / 低酸素 / 低酸素誘導因子-1α / β-カテニン / バイオアッセイ / 食品成分 / 前立腺がん |
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| Research Abstract |
Androgen receptor regulates the expression of some genes involved in proliferation and progression of prostate cancer. In the present study, we identified hypoxia-inducible factor-1a (HIF-1a) and b-catenin as cooperative AR coactivators under hypoxic conditions and demonstrated the molecular mechanisms by which these coactivators enhanced AR transactivation. Furthermore, we constructed a rapid yeast bioassay for androgenic and anti-androgenic compounds based on the molecular mechanisms and analyzed anti-androgenic activity of food components.
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[Journal Article] Sensitive and convenient yeast reporter assay for high-throughput analysis by using a secretory luciferase from Cypridina noctiluca.2010
Author(s)
Tochigi Y, Sato N, Sahara T, Wu C, Saito S, Irie T. Fujibuchi W, Goda T, Yamaji R, Ogawa M, Ohmiya Y, Ohgiya S.
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Journal Title
Anal.Chem 82
Pages: 5768-5776
Peer Reviewed
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