2010 Fiscal Year Final Research Report
Regulatory mechanisms for the proliferation and invasion under oxidative stress via modulation of membranous glycolipids.
| Project/Area Number |
20580369
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied molecular and cellular biology
|
|---|
| Research Institution | Tokyo University of Agriculture and Technology |
|---|
Principal Investigator |
MIURA Yutaka Tokyo University of Agriculture and Technology, 大学院・農学研究院, 准教授 (10219595)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 癌細胞浸潤 / 酸化ストレス / 細胞膜糖脂質 / ガングリオシド |
|---|
| Research Abstract |
The regulatory mechanisms for the protentiation of mouse melanoma cell invasion under hypoxic condition were investigated. The increase in membranous ganglioside GM3 contents and the modulation of proteins-glycolipids complex in cell membrane were proved to be deeply involved in this phenomenon. This result indicates novel mechanisms for cancer aggravation under hypoxia.
|
-
-
-
-
-
[Journal Article] Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage.2009
Author(s)
Fujiyama-Nakamura S, Yoshikawa H, Homma K, Hayano T, Tsujimura, Takahashi T, Izumikawa K, Ishikawa H, Miyazawa N, Yanagida M, Miura Y, Shinkawa T, Yamauchi Y, Isobe T, Takahashi N.
-
Journal Title
Molecular and Cellular Proteomics 8
Pages: 1552-1565.
Peer Reviewed
-
-
-
-
-
-
-
