2010 Fiscal Year Final Research Report
Development and application of the environmental friendly organic synthesis using characteristics of the heterocycle
| Project/Area Number |
20590025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
KAWASAKI Ikuo Mukogawa Women's University, 薬学部, 准教授 (00234055)
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| Co-Investigator(Renkei-kenkyūsha) |
西出 喜代治 武庫川女子大学, 薬学部, 教授 (10237711)
田渕 裕佳子 武庫川女子大学, 薬学部, 助手 (80509943)
山下 正行 京都薬科大学, 薬学部, 教授 (20239982)
久留米 愛 京都薬科大学, 薬学部, 助手 (40454475)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 有機合成 / 複素環 / 不斉還元 / リサイクル / イオン性化合物 / イオン液体 / リガンド / 触媒 |
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| Research Abstract |
A novel chiral ionic ligand which has the structure of the quaternary ammonium salt in the nitrogen containing heterocycle was prepared, and asymmetric reduction of prochiral ketone proceeded well when the ionic ligand with Ru and formic acid as a hydrogen source was used for catalytic asymmetric transfer hydrogenation (CATH). This reaction system of CATH could be expanded to recycling CATH (RCATH) by using ionic liquid as a reaction medium. Thus, I could achieve the development of the environmental friendly organic synthesis used a characteristic of the heterocycle. Furthermore, this reaction system of RCATH could be applied to the synthesis of pharmaceutical useful compound, and I succeeded in the asymmetric synthesis of the pharmaceutical product.
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