2010 Fiscal Year Final Research Report
Development and application of novel environmental harmonized tandem reaction catalyzed by typical metal salt
| Project/Area Number |
20590027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hiroshima International University |
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Principal Investigator |
YANADA Reiko Hiroshima International University, 薬学部, 教授 (80239821)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 金属塩 / 触媒反応 / 環境調和型 / タンデム反応 / 2-アルキニルベンズアミド / 超原子価ヨウ素試薬 / ホフマン型転位 / イソシアネート |
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| Research Abstract |
Starting from 2-alkynylbenzaldehydes and 2-alkynylanilines, In(OTf)3-catalyzed synthesis of ring-condensed heteroaromatic compounds was developed via a domino intramolecular nucleophilic attack/intermolecular cycloaddition/dehydration reaction. And a concise one-pot synthesis of indoles and isoquinolines from isocyanates which are derived from a Hofmann-type rearrangement of amides using a hypervalent iodine reagent was also developed.
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Research Products
(20 results)
