2010 Fiscal Year Final Research Report
セレン蛋白質GPx4による新規細胞増殖制御機構の解析
| Project/Area Number |
20590067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
IMAI Hirotaka Kitasato University, 薬学部, 准教授 (50255361)
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| Project Period (FY) |
2008 – 2010
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| Keywords | グルタチオンペルオキシダーゼ / 細胞死 / リピドミクス / 化合物ライブラリー / ビタミンE / 脂質酸化 / 非アポトーシス / セレン蛋白質 |
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| Research Abstract |
Phospholipid hydroperoxide glutathione peroxidase (GPx4) is one of the most important antioxidant enzymes that directly reduce phospholipid hydroperoxide generated in biomembrane by oxidative stress. Disruption of GPx4 induce cell death in in several tissues and MEF cells. Several experiments demonstrated that this cell death induced by depletion of GPx4 is not a canonical cell death, such as apoptosis, necrosis and autophagic cell death, but a novel cell death.
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[Journal Article]2009
Author(s)
Imai H., Hakkaku N., Iwamoto R., Suzuki J., Suzuki T., Tajima Y., Konishi K., Minami S., Ichinose S., Ishizaka K., Shioda S., Arata S., Nishimura M., Naito S., Nakagawa Y.
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Journal Title
J.Biol.Chem. 284
Pages: 32522-32532
Peer Reviewed
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