2010 Fiscal Year Final Research Report
Analysis of responsive factors for oxidative stress mediated by O-GlcNAc modification
| Project/Area Number |
20590082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
MIURA YURI Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 主任研究員 (00216574)
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| Project Period (FY) |
2008 – 2010
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| Keywords | シグナル伝達 / 酸化ストレス / アポトーシス / ストレス応答タンパク質 |
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| Research Abstract |
In order to clarify the regulation mechanisms by O-GlcNAcylation in the signaling pathways caused by reactive oxygen species, the alteration of O-GlcNAcylated proteins due to oxidative stress and the effects of O-GlcNAcylation on the induction of stress responsive proteins were examined. The results suggest that O-GlcNAcylated proteins play a critical role of oxidative stress-responses, and that the induction of stress responsive protein is possible to be regulated by O-GlcNAcylation.
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[Journal Article] Proteomic Analysis of Plasma Proteins in Japanese Semisuper Centenarians.2011
Author(s)
Miura, Y., Sato, Y., Arai, Y., Abe, Y., Takayama, M., Toda, T., Hirose, N., Endo, T.
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Journal Title
Exp. Gerontol. 46
Pages: 81-85
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[Journal Article] Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes.2010
Author(s)
Miura, Y., Sakurai, Y., Hayakawa, M., Shimada, Y., Zempel, H., Sato, Y., Hisanaga, S., Endo, T.
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Journal Title
Biol. Pharm. Bull 33
Pages: 22-28
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