2010 Fiscal Year Final Research Report
Progression of atherosclerosis in hypertriglyceridemic rabbit
| Project/Area Number |
20590087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Yamagata University (2009-2010)
Ohu University (2008) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATANO Yumi 山形大学, 医学部, 名誉教授 (70018696)
ITOH Tsunekata 山形大学, 医学部, 助手 (80241719)
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| Project Period (FY) |
2008 – 2010
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| Keywords | トリグリセリド / 動脈硬化 / ウサギ |
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| Research Abstract |
Postprandial hypertriglyceridemic rabbits (PHT) showed vascular endothelial dysfunction. The vascular reactivity to angiotensin and urotensin was not significantly different. The lipid peroxidation was increased in plasma and visceral fat of PHT rabbits. The accumulation of peroxynitrite could be responsible for endothelial injury and atherosclerosis.
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Research Products
(14 results)
