2010 Fiscal Year Final Research Report
Development of stereoselective cascade hetero-cycloaddition reaction and its application to the synthesis of biologically active natural products
| Project/Area Number |
20590101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | University of Toyama |
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Principal Investigator |
HIRAI Yoshirou University of Toyama, 事務局, 理事・副学長 (70111747)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 医薬品化学 |
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| Research Abstract |
Total synthesis of (+)-dienomycine which is piperidine alkaloid, synthesis of tetrahydropyran frame of yessotoxin, novel synthesis of sugars such as D-ribose, D-deoxyriboe, and spiroC-arylglycoposide derivatives, and the spiroketal ring which is the basic skeleton of spirofungins through the Pd catalyzed cyclization were done well. Stereo-selective construction of the conjugate dienes which are parts of spirofungins also were developed.
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Research Products
(36 results)
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[Journal Article] Total synthesis of(+)-dienomycin C2010
Author(s)
Yokoyama, H., Hayashi, Y., Nagasawa, Y., Ejiri, H., Miyazawa, M., Hirai, Y.
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Journal Title
Tetrahedron 66
Pages: 8458-8463
Peer Reviewed
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[Journal Article] Synthesis of SpirC-Arylglycoriboside via Pd(II)-Catalyzed Spirocyclization2010
Author(s)
Awasaguchi, K., Miyazawa, M., Uoya, I., Inoue, K., Nakamura, K., Yokoyama, H., Kakuda, H., Hirai, Y.
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Journal Title
Peer Reviewed
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[Journal Article] A Novel Pentose Synthesis via Palladium(II)-catalyzed cyclization of an unstable Hemiacetal2010
Author(s)
Awasaguchi, K., Miyazawa, M., Uoya, I., Inoue, K., Nakamura, K., Yokoyama, H., Hirai, Y.
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Journal Title
Heterocycles 81
Pages: 2105-2121
Peer Reviewed
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[Journal Article] Pd(II)-catalyzed cyclization to ether and its application to the synthesis of the trans-fused polyether core2009
Author(s)
Yokoyama, H., Nakayama, S., Murase, M., Miyazawa, M., Yamaguchi, S., Hirai, Y.
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Journal Title
Heterocycles 77
Pages: 211-215
Peer Reviewed
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