2010 Fiscal Year Final Research Report
Development of novel class of Cdc25A inhibitor by combination of hydrophilic and hydrophobic group
| Project/Area Number |
20590110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SHIMAZAWA Rumiko Tohoku University, 大学院・医歯薬学総合研究科, 准教授 (00411083)
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| Co-Investigator(Kenkyū-buntansha) |
KURIYAMA Masami 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (40411087)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脱リン酸化酵素 / Cdc25A / 複素環 / 付加反応 |
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| Research Abstract |
Novel N-heterocyclic derivatives were designed and synthesized as a Cdc25A inhibitor. The N-heterocyclic derivatives which have long alkyl chains exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A. In addition, efficient synthesis of 3-arylphthalides via palladium-catalyzed 1,2-addition with the novel thioether-imidazolinium carbene ligands was successfully achieved.
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