2010 Fiscal Year Final Research Report
Study on evaluation system for drug cardiotoxicity using on-chip cell-besed analysis and quality examination of generic products of injection
| Project/Area Number |
20590147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKASHIMA Mikiro Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (00260737)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Hitoshi 長崎大学, 病院, 教授 (00170689)
NAKASHIMA Mihoko 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (00301367)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 医薬品情報 / 安全性学 / 後発医薬品 / 品質試験 / 毒性試験 / 薬剤応答性 / セロミクス / 動物実験 |
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| Research Abstract |
We investigated the pharmaceutical quality and safety of generic products of injection using a cultured cell and an experimental animal, and examined the development of the method to evaluate drug cardiotoxicity by an on-chip cardiomyocyte network cell-based analysis. As a result, monitoring of effects on the beating rhythms of the network cells after treatment of agents could us estimate the ionic channel conditions, suggesting that it might be useful as a cell-based measurement system for drug cardiotoxicity. The pharmaceutical quality and safety of generic injections tested in this study were comparable to the innovator injections.
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