2010 Fiscal Year Final Research Report
Influence of CYP2D6, CYP3A4/5 & Sulfotransferase 1A1 polymorphism on the pharmacokinetics of Tamoxifen.
| Project/Area Number |
20590156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
KUBOTA Takahiro Chiba Institute of Science, 薬学部, 准教授 (50323580)
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| Project Period (FY) |
2008 – 2010
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| Keywords | オーダーメード医療 / 臨床薬学 |
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| Research Abstract |
We have studied the analysis of the mutant alleles CYP2D6, CYP3A4/5, and SULT1A1 enzymes, which are known to be present in Japanese individuals, on themetabolic activity of tamoxifen. In addition, we are comparing the relationship between p-nitrophenol metabolic activity and SULT1A1 genetic polymorphism using an ex vivo evaluation method in 101 healthy Japanese adults.
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[Journal Article] Thiopurine maintenance therapy for ulcerative colitis-the clinical significance of monitoring 6-thioguanine nucleotide.2010
Author(s)
Hanai H, Iida T, Takeuchi K, Arai O, Watanabe F, Abe J, Maruyama Y, Oohata A, Ikeya K, Kageoka M, Miwa I, Satou Y, Hosoda Y, Kubota T.
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Journal Title
Inflamm Bowel Dis 16
Pages: 1376-1381
Peer Reviewed
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