2010 Fiscal Year Final Research Report
Elucidation of the functional roles of VEGF-positive stromal cells during angiogenesis
| Project/Area Number |
20590199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
MORIKAWA Shunichi Tokyo Women's Medical University, 医学部, 助教 (70339000)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血管新生 / 周皮細胞 / 間質細胞 / 創傷治癒 / VEGF / 多重免疫染色 / 電子顕微鏡 / 心筋シート |
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| Research Abstract |
It is strongly suggested that amongst VEGF-positive stromal cells, pericytes play major roles in the angiogenesis during wound-healing. They presumably promote proliferation and extension of blood vessels in the early stage of angiogenesis, whereas in the later stage, they in turn stabilize newly formed vessels, via such as NG2 signaling pathway. It is also suggested that fibroblasts positive for VEGF along with multiple pericyte markers serve as pericyte precursors during wound-healing.
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Research Products
(26 results)
