The effect of temperature and morphology on insulin secreting signal and insulin secretion in insulin secreting cells

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590208
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: MOGAMI Hideo Hamamatsu University School of Medicine, 医学部, 准教授 (90311604)
• Co-Investigator(Kenkyū-buntansha): TERAKAWA Susumu (50014246) ; SAKURAI Takashi (50283362)
• Project Period (FY): 2008 – 2010
• Keywords: 膵β細胞 / 細胞内情報伝達 / インスリン / 生体温度 / 形態

Research Abstract

The effect of temperature and morphology on insulin secretion has been shown using either TRPM2 or Cx36 knockdown pseudoislets.

Research Products

• [Journal Article] A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy. (2009)
  • Author(s): Eisuke Adachi, Yutaka Kazoe, Yohei Sato, Yuko Suzuki, Tetsumei Urano, Takehiko Ueyama, Naoaki Saito, Viacheslav O.Nikolaev, Martin J. Lohse, Makoto Tominaga, Hideo Moeami
  • Journal Title: Pfluger Archives-European Journal of Physiology 459 Pages: 227-234
  • Peer Reviewed
• [Journal Article] Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. (2009)
  • Author(s): Nakagawa Y, Nagasawa M, Yamada S, Hara A, Moeami H, Nikolaev VO, Lohse, MJ, Shigemura N, Ninomiya, Y, Kojima I
  • Journal Title: PLoS ONE 4 Pages: e5160
  • Peer Reviewed
• [Journal Article] Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells. (2009)
  • Author(s): Suzuki Y, Moeami H. Ihara H, Urano T
  • Journal Title: Blood 113 Pages: 470-478
  • Peer Reviewed
• [Journal Article] Real-time analysis of platelet aggregation and procoagulant activity during thrombus formation in vivo. (2008)
  • Author(s): Hayashi T, Moeami H, Murakami Y, Nakamura T, Kanayama N, Konno H, UranoT.
  • Journal Title: Pfluger Archives-Eur J Physiol. 456 Pages: 1239-1351
  • Peer Reviewed
• [Presentation] Secretagogue-induced multiple signal interconnections in insulin secreting cells. (2010)
  • Author(s): Moeami H
  • Organizer: 14^<th> International congress of endocrinlogy
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100300
• [Presentation] Secretagogue-induced multiple signal interconnections in insulin secreting cells. (2009)
  • Author(s): Moeami H
  • Organizer: 36^<th> International congress of physiological science
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090700
• [Presentation] Real-time analysis of platelet aggregation and procoagulant activity during thrombus formation in vivo Frontiers of Biological Imaging (2008)
  • Author(s): Moeami H
  • Organizer: 39^<th> NIPS International Symposium & 7^<th> OIB Symposium
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 20080900
• [Book] 血栓止血誌(技術講座「生体内リアルタイムイメージングによる血栓形成過程の解析」) (2008)
  • Author(s): 浦野哲盟、鈴木優子、林忠毅、最上秀夫
• [Book] 血栓止血誌(血液及び血管内皮からみた血栓症リスク) (2008)
  • Author(s): 浦野哲盟、鈴木優子、井原勇人、最上秀夫
  • Total Pages: 419-494
• [Remarks] ホームページ等