2010 Fiscal Year Final Research Report
Analysis of ATP-dependency of Na^+/Mg^<2+> exchange
| Project/Area Number |
20590219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
YOKOYAMA Michiko Tokyo Medical University, 医学部, 講師 (20398762)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生体膜 / チャネル / トランスポーター / 能動輸送 |
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| Research Abstract |
We studied Na^+/Mg^2+ transport rate after metabolic inhibition in rat ventricular myocyte. A decrease in ATP below the threshold of rigor cross-bridge formation, rather than elevation of [Na^+]i or intracellular acidosis, inhibits the Mg^2+ efflu～90%), suggesting the absolute necessity of ATP for the Na6+/Mg^2+ exchange.
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