2010 Fiscal Year Final Research Report
Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasis
| Project/Area Number |
20590289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tokai University |
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Principal Investigator |
NAKAYAMA Yukari (六車 ゆかり) Tokai University, 医学部, 特定研究員 (80398750)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Kiyoshi 東海大学, 医学部, 教授 (70176014)
YAHATA Takashi 東海大学, 医学部, 講師 (10398753)
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| Co-Investigator(Renkei-kenkyūsha) |
HOZUMI Katsuto 東海大学, 医学部, 准教授 (30246079)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 再生医学 / 骨と骨髄 |
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| Research Abstract |
We analyzed the skeletal phenotypes and bone metabolisms of two of Notch ligands transgenic mice, in which Jagged 1(J1) or Delta-like ligand 1 (Dll1) was over-expressed or conditionally deleted. The results revealed for the first time that the Notch signal regulated and maintained bone homeostasis in a ligand specific manner. In addition, the Notch signal indirectly influenced the hematopoietic homeostasis through the proper supply of the hematopoietic stem cell niche in bone marrow, where hematopoiesis primarily occurs throughout the adult life. These results have an important meaning for the development of novel treatment for diseases caused by an abnormal bone metabolism and/or hematopoietic disorders.
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