2010 Fiscal Year Final Research Report
A role of Tumor Suppressor Fhit Product in Cell Death, Survival and Carcinogenesis
| Project/Area Number |
20590313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
石井 秀始 Kyushu University, 生体防御医学研究所 (10280736)
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| Co-Investigator(Kenkyū-buntansha) |
三森 功士 (50322748)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 癌抑制遺伝子 / 活性酸素 / ゲノム / 染色体 |
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| Research Abstract |
More than 12 years and >800 scientific publications after the discovery of the first gene at a chromosome fragile site, the FHIT gene at FRA3B, there are still questions to pursue concerning the selective advantage conferred to cells by loss of expression of FHIT, the most frequent target of allele deletion in precancerous lesions and cancers. These questions include how the cell death of cancer cells are prohibited by deficiency or alterations of FHIT gene and cancer cells would survive in the microenvironment ; the Fhit protein can be phosphorylated though the response to extracellular stimuli. Thus this notion is considered in light of recent investigations of genetic and epigenetic alterations to the locus and in a retrospective consideration of biological roles of the Fhit protein discovered through functional studies.
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[Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab.2010
Author(s)
Nishida, N.,Mimori, K.Fabbri, M.Yokobori, T.Sudo, T.Tanaka, F.Shibata, K., Ishii, H.Doki, Y.Mori, M.
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Journal Title
Clin.Cancer Res.[Epubahead of print] (in press)
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[Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.2010
Author(s)
Tanaka, F.Yamamoto, K.Suzuki, S.Inoue, H.Tsurumaru, M.Kajiyama, Y.Kato, H.Igaki, H.Furuta, K.Fijita, H.Tanaka, T.Tanaka, Y.Kawashima, Y.Natsugoe, S.Setoyama, T.Tokudome, S.Mimori, K.Haraguchi, N.Ishii, H.Mori, M.
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Journal Title
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[Journal Article] A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases.2008
Author(s)
Mimori, K.Fukagawa, T.Kosaka, Y.Ishikawa, K.Iwatsuki, M.Yokobori, T.Hirasaki, S.Takatsuno, Y.Sakashita, H.Ishii, H., et.al
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Journal Title
An.Surg.Oncol. 15(10)
Pages: 2934-2942
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[Journal Article] Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.2008
Author(s)
Ohta, M.Mimori, K.Fukuyoshi, Y.Kita, Y.Motoyama, K.Yamashita, K.Ishii, H., Inoue, H., Mori, M.
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Journal Title
Br.J.Cancer 98(2)
Pages: 410-417
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[Book] Cancer Drugs Discovery and Development : Stem Cells and Cancer.(Cancer stem cells : gastrointestinal cancers, Chapter 12. In : the 1st edition book entitled)(Book Editors: Rebecca G. Bagley, MS, and Beverly A. Teicher, PhD. Publisher)2009
Author(s)
Ishii H., Haraguchi N., Ieta, K., Mimori K., Mori M.
Total Pages
DOI:10.1007/978-1-60327-933-8_12
Publisher
Publisher : Springer Science & Humana Press, Inc.(in press)
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