2010 Fiscal Year Final Research Report
Analyses of a vesicular transport protein taxilin in tumorigenesis
| Project/Area Number |
20590314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
ITOH Masahiko 獨協医科大学, 医学部, 准教授 (70270486)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 癌 / 転移 / 浸潤 / 細胞増殖 / 小胞輸送 |
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| Research Abstract |
A putative vesicular transport protein, taxilin, is expressed in secreting cells such as neuroendocrine cells in the normal colon and rectum. On the other hand, its expression appeared to be elevated in the colon cancer, prostate cancer, and breast cancer as well as in glioblastoma, osteosarcoma, and melanoma cells. The suppression of taxilin in the metastatic breast cancer cell line induced the reduction of cell growth and invasiveness and upregulted the susceptibility to anti-cancer drug, suggesting its functional implication in the specific type of cancer.
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[Journal Article] Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells2008
Author(s)
Katsuno T, Umeda K, Matsui T, Hata M, Tamura A, Itoh M, Takeuchi K, Fujimori T, Nabeshima Y, Noda T, Tsukita S, Tsukita S
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Journal Title
Mol Biol Cell
Volume: vol.19(6)
Pages: 2465-2475
DOI
Peer Reviewed
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