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2010 Fiscal Year Final Research Report

Identification of a novel chimera gene not involving PAX family gene in rhabdomyosarcoma cell lines

Research Project

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Project/Area Number 20590365
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionShimane University

Principal Investigator

KAKAZU Naoki  島根大学, 医学部, 准教授 (20264757)

Project Period (FY) 2008 – 2010
Keywords横紋筋肉腫 / 染色体転座
Research Abstract

Rhabdomyosarcoma(RMS) is characterized by the specific chromosomal translocations involving 2q35 and 1p36 bands, which generate the PAX3-and PAX7-related chimera genes, respectively. We analyzed RMS cell lines by spectral karyotyping(SKY) and detected many chromosomal translocations, in which the PAX3 and PAX7 genes were not involved. We analyzed their breakpoint regions by FISH but could not identify novel chimera genes, which suggests that the translocations were secondarily caused by chromosomal instability due to the RMS development.

  • Research Products

    (1 results)

All 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Restoration of p53 pathway by Nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells2009

    • Author(s)
      Miyachi M, Kakazu N, Yagyu S, Katsumi Y, Tsubai-Shimizu S, Kikuchi K, Tsuchiya K, Iehara T, Hosoi H.
    • Journal Title

      Clin Cancer Res

      Volume: 15 Pages: 4077-4084

    • Peer Reviewed

URL: 

Published: 2013-07-31  

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