2010 Fiscal Year Final Research Report
Identification of a novel chimera gene not involving PAX family gene in rhabdomyosarcoma cell lines
| Project/Area Number |
20590365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Shimane University |
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Principal Investigator |
KAKAZU Naoki 島根大学, 医学部, 准教授 (20264757)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 横紋筋肉腫 / 染色体転座 |
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| Research Abstract |
Rhabdomyosarcoma(RMS) is characterized by the specific chromosomal translocations involving 2q35 and 1p36 bands, which generate the PAX3-and PAX7-related chimera genes, respectively. We analyzed RMS cell lines by spectral karyotyping(SKY) and detected many chromosomal translocations, in which the PAX3 and PAX7 genes were not involved. We analyzed their breakpoint regions by FISH but could not identify novel chimera genes, which suggests that the translocations were secondarily caused by chromosomal instability due to the RMS development.
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