2010 Fiscal Year Final Research Report
Functional analysis of CRISP homologues of schistosome
| Project/Area Number |
20590435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
KANAZAWA Tamotsu University of Occupational and Environmental Health, Japan, 医学部, 教授 (10194888)
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| Co-Investigator(Kenkyū-buntansha) |
OSADA Yoshio 産業医科大学, 医学部, 准教授 (80282515)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEO Satoru 愛媛大学, 無細胞生命科学工学研究センター, 講師 (40302666)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 感染症 / 寄生虫 / 住血吸虫 / 免疫回避 / 分泌タンパク / CRISP / SCP / Tpx-1 / PR-1 |
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| Research Abstract |
Venom allergen-like proteins (VALs) are schistosome homologues of secreted proteins CRISP/SCP/Tpx-1/PR-1 widely distributed among various species of organisms and their biological roles are unknown. In this study we have successfully cloned some of the VAL molecules from Schistosoma mansoni. VAL-3 augmented production of an immunosuppresiive cytokine IL-10 from mouse spleen cells. This result suggest the possibility that VAL molecules might be involved in the parasite-induced immunomodulation.
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