2010 Fiscal Year Final Research Report
Bacterial internalization into cytosol-dependent caspase-1 activation in Listeria-infected murine macrophages
Project/Area Number |
20590440
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Kyoto University |
Principal Investigator |
NOMURA Takamasa Kyoto University, 人間生活学部, 講師 (40362529)
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Project Period (FY) |
2008 – 2010
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Keywords | リステリア / カスパーゼ / オートファジー / サイトカイン |
Research Abstract |
The mechanism of IL-1α/β production from Listeria monocytogenes-infected macrophages was elucidated. L. monocytogenes internalized into cytoplasmic space was recognized by AIM2 which was a pattern recognition receptor of host cells. Formation of inflammsome containing ASC was induced and activated the caspase-1 resulting to maturation of IL-1β In addition, bacterial entry into cytoplasm also activated calcium signaling pathway. Calcium signals should activate a Calcium-dependent protease,calpain resulting to IL-1α maturation and release of mature IL-1α/β by autophagy or secretary lysosome pathways.
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Research Products
(9 results)
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[Journal Article] Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages.2010
Author(s)
Shen Y., Kawamura I., Nomura T., Tsuchiya K., Hara H., Dewamitta S.R., Sakai S., Qu H., Daim S., Yamamoto T., Mitsuyama M.
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Journal Title
Infection and Immunity 78(6)
Pages: 2857-2867
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[Journal Article] Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes.2010
Author(s)
Dewamitta S.R., Nomura T., Kawamura I., Hara T., Tsuchiya K., Kurenuma T., Shen Y., Daim S., Yamamoto T., Qu T., Sakai S., Xu Y., Mitsuyama M.
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Journal Title
Infection and Immunity. 78(5)
Pages: 1884-18894
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