2010 Fiscal Year Final Research Report
Fluctuation of virus growth via activation of TLR signaling pathway.
| Project/Area Number |
20590476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
FUJII Nobuhiro Sapporo Medical University, 医学部, 教授 (90133719)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOTA Shinーichi 札幌医科大学, 医学部, 准教授 (10325863)
OKABAYASHI Tamaki 札幌医科大学, 医学部, 講師 (10359995)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 病原性 / 感染免疫 |
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| Research Abstract |
We investigated the fluctuation of virus growth via activation of TLR signaling pathway in persistently or acutely infected cells with measles, mumps or herpes simplex viruses. The fluctuation was not recognaized in lymphoid cell lines persistently infected with these viruses through treatment with LPS or HSP. On the other hand, release of herpes simplex virus type 1 was significantly suppressed by pretreatment of FL cells with imiquimod.
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