2010 Fiscal Year Final Research Report
Regulation of inflammation through Mitogen-activated protein kinases
| Project/Area Number |
20590488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Mie University |
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Principal Investigator |
OGATA Masato Mie University, 大学院・医学系研究科, 教授 (60224094)
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| Project Period (FY) |
2008 – 2010
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| Keywords | リンパ球 / MAPキナーゼ / ERK / p38 / 遺伝子改変マウス / 慢性炎症 |
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| Research Abstract |
Mitogen-activated protein kinases (MAPKs) such as ERK and p38 are involved in the regulation of inflammation and various biological phenomena through signal transductions. To elucidate the in vivo functions of ERK and p38, we have established ERK2 and p38α conditional knockout mice. The study of these mice revealed that ERK2 and p38α are involved in the regulation of lymphocyte development and metabolic syndrome, respectively. These results suggest that signaling molecules in the MAPK pathways are candidate targets to control immune responses and/or chronic inflammation induced by obesity.
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[Journal Article] DIP/WISH-deficient mice reveal Dia-and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts.2009
Author(s)
Fukumi-Tominaga, T., Mori, Y., Matsuura, A., Kaneko, K., Matsui, M., Ogata, M., Tominaga, M.
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Journal Title
Genes Cells 14
Pages: 1197-1207
Peer Reviewed
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[Journal Article] Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.2008
Author(s)
Yasuda, T., San jo, H., Pages, G., Kawano, Y., Karasuyama, M., Pouyssegur, J., Ogata, M., Kurosaki, T.
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Journal Title
Immunity 28
Pages: 499-508
Peer Reviewed
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