2010 Fiscal Year Final Research Report
Clinical and genetic factors of drug-induced QT interval prolongation in patients who receive cancer chemotherapy
| Project/Area Number |
20590537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
ANDO Yuichi Nagoya University, 医学部附属病院, 准教授 (10360083)
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| Co-Investigator(Kenkyū-buntansha) |
SAWAKI Masataka 名古屋大学, 大学院・医学研究科, 特任講師 (20402597)
MITSUMA Ayako 名古屋大学, 大学院・医学研究科, 特任助教 (10467326)
SATO Mitsuo 国立長寿医療センター病院, 医長 (70467281)
KAWADA Kenji 名古屋大学, 医学部附属病院, 病院助手 (30418743)
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| Project Period (FY) |
2008 – 2010
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| Keywords | がん化学療法 / QT延長 / 医薬品副作用 / 遺伝子多型 |
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| Research Abstract |
This study assessed the characteristics of QT intervals and arrhythmias in women with breast cancer who received chemotherapy with a combination of epirubicin, cyclophosphamide and 5-fluorouracil. QT intervals could be measured in 127 records in 34 patients. There was a significant trend toward QT interval prolongation after each treatment. No patient had serious arrhythmias. There was no association between QT interval prolongation and the SNPs of potassium channel genes.
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