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2012 Fiscal Year Final Research Report

Searching genes susceptible for life-style related diseases, such as diabetes and hypertension.

Research Project

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Project/Area Number 20590595
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionYamagata University

Principal Investigator

DAIMON Makoto  山形大学, 大学院・医学研究科, 准教授 (20241698)

Project Period (FY) 2008 – 2012
Keywords分子遺伝疫学
Research Abstract

Most studies to find genes susceptible for life-style related diseases have been conducted without regard for life-style per se. This strategy conveys a risk that the results obtained were not useful in ordinary clinical settings. Therefore, we search genes susceptible for life-style related diseases with detailed information of life-styles such as nutritional intakes and physical activities, and found several genes susceptible for life-style related diseases. Of them, tow genes (GNB3 and FTO) were found as associated with diabetes in relation with salt intake and obesity in relation with physical activities, respectively. These findings seem to be very useful in ordinary clinical settings.

  • Research Products

    (28 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] Lower physical activity is a risk factor for a clustering of metabolic risk factors in non-obese and obese Japanese subjects: The Takahata study2013

    • Author(s)
      Kaino W, Daimon M, Sasaki S, et al.
    • Journal Title

      Endocr J

    • DOI

      DOI:10.1507/endocrj.EJ12-0351

    • Peer Reviewed
  • [Journal Article] Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians2012

    • Author(s)
      Li H, Kilpelainen TO, Liu C, et al.
    • Journal Title

      Diabetologia

      Volume: 55 Pages: 981-995

    • DOI

      DOI:10.1007/s00125-011-2370-7.

    • Peer Reviewed
  • [Journal Article] Higher plasma renin activity is a risk factor for total mortality in older Japanese individuals: the Takahata study2012

    • Author(s)
      Daimon M, Konta T, Oizumi T, et al.
    • Journal Title

      Metabolism

      Volume: 61 Pages: 504-511

    • DOI

      DOI:10.1016/j.metabol.2011.08.004.

    • Peer Reviewed
  • [Journal Article] Plasma fibrinogen, global cognitive function, and cerebral small vessel disease: results of a cross-sectional study in community-dwelling Japanese elderly2011

    • Author(s)
      Wada M, Takahashi Y, Iseki C, et al.
    • Journal Title

      InternMed

      Volume: 50 Pages: 999-1007

    • DOI

      DOI:/10.2169/internalmedicine.50.4752

    • Peer Reviewed
  • [Journal Article] Association of the clusterin gene polymorphisms with type 2 diabetes mellitus2011

    • Author(s)
      Daimon M, Oizumi T, Karasawa S, et al.
    • Journal Title

      Metabolism

      Volume: 60 Pages: 815-822

    • DOI

      DOI:10.1016/j.metabol.2010.07.033.

    • Peer Reviewed
  • [Journal Article] Relationship between alcohol consumption and serum adiponectin levels: the Takahata study-a cross-sectional study of a healthy Japanese population2010

    • Author(s)
      Nishise Y, Saito T, Makino N, et al.
    • Journal Title

      J Clin EndocrinolMetab

      Volume: 95 Pages: 3828-3835

    • DOI

      DOI:10.1210/jc.2009-1862.

    • Peer Reviewed
  • [Journal Article] Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population2010

    • Author(s)
      Karasawa S, Daimon M, Sasaki S, et al.
    • Journal Title

      EndocrJ

      Volume: 57 Pages: 293-301

    • DOI

      DOI:10.1507/endocrj.K09E-305

    • Peer Reviewed
  • [Journal Article] Cystatin C as an index of cerebral small vessel disease: results of a cross-sectional study in community-based Japanese elderly2010

    • Author(s)
      Wada M, Nagasawa H, Kawanami T, et al.
    • Journal Title

      EurJ Neurol

      Volume: 17 Pages: 383-390

    • DOI

      DOI:10.1111/j.1468-1331.2009.02809.x.

    • Peer Reviewed
  • [Journal Article] Impact of metabolic syndrome on elevated serum alanine aminotransferase levels in theJapanese population2009

    • Author(s)
      Saito T, Nishise Y, Makino N, et al.
    • Journal Title

      Metabolism

      Volume: 58 Pages: 1067-1075

    • DOI

      DOI:10.1016/ j.metabol.2009.03.008.

    • Peer Reviewed
  • [Journal Article] Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM2009

    • Author(s)
      Daimon M, Oizumi T, Toriyama S, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 386 Pages: 26-29

    • DOI

      DOI:10.1016/j.bbrc. 2009.05.119.

  • [Journal Article] Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population2008

    • Author(s)
      Daimon M, Sato H, Oizumi T, et al.
    • Journal Title

      Biochem BiophysRes Commun

      Volume: 365 Pages: 466-471

    • DOI

      DOI:10.1016/j.bbrc.2007.10.180

    • Peer Reviewed
  • [Journal Article] Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations2008

    • Author(s)
      Iijima H, Emi M, Wada M, et al.
    • Journal Title

      J HumGenet

      Volume: 53 Pages: 193-200

    • DOI

      DOI:10.1007/s10038-007-0236-0

    • Peer Reviewed
  • [Journal Article] A functional polymorphism of the TNF-alpha gene that is associated with type 2 DM2008

    • Author(s)
      Susa S, Daimon M, Sakabe J, et al.
    • Journal Title

      Biochem BiophysRes Commun

      Volume: 369 Pages: 943-947

    • DOI

      DOI:10.1016/j.bbrc. 2008.02.121.

    • Peer Reviewed
  • [Journal Article] Cerebral small vessel disease and chronic kidney disease (CKD): results of a cross-sectional study in community-based Japanese elderly2008

    • Author(s)
      Wada M, Nagasawa H, Iseki C, et al.
    • Journal Title

      JNeurolSci

      Volume: 272 Pages: 36-42

    • DOI

      DOI:10.1016/j.jns.2008. 04.029.

    • Peer Reviewed
  • [Journal Article] Salt consumption-dependent association of the GNB3 gene polymorphism with type 2DM2008

    • Author(s)
      Daimon M, Sato H, Sasaki S, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 374 Pages: 576-580

    • DOI

      DOI:10.1016/j.bbrc. 2008.07.065.

    • Peer Reviewed
  • [Journal Article] Genetic association between aldehyde dehydrogenase 2 (ALDH2) variation and high-density lipoprotein cholesterol (HDL-C) among non-drinkers in two large population samples in Japan2008

    • Author(s)
      Wada M, Daimon M, Emi M, et al.
    • Journal Title

      JAtheroscler Thromb

      Volume: 15 Pages: 179-184

    • DOI

      DOI:10.5551/jat.E542

    • Peer Reviewed
  • [Presentation] Decreased physical activity is associated with a clustering of metabolic risk factors in non-obese and obese Japanese subjects2012

    • Author(s)
      Kaino W, et al
    • Organizer
      9^<th> International Diabetes Federation-Western Pacific Region Meeting,Kyoto
    • Place of Presentation
      京都国際会館
    • Year and Date
      2012-11-02
  • [Presentation] 動脈硬化性疾患の危険因子の重積は身体活動量と関連している2012

    • Author(s)
      海野航, 他
    • Organizer
      第55回日本糖尿病会年次学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-05-18
  • [Presentation] 血漿レニン活性高値は全死亡の危険因子2012

    • Author(s)
      大門真, 他
    • Organizer
      第85回日本内分泌学会年次学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-04-19
  • [Presentation] 5年後の糖尿病発症リスクを指標とした耐糖能の評価基準の検討2011

    • Author(s)
      大門真, 他
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌市教育文化会館
    • Year and Date
      2011-05-20
  • [Presentation] 地域住民における耐糖能障害と悪性新生物発症との関連2011

    • Author(s)
      大泉俊英, 他
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌市教育文化会館
    • Year and Date
      2011-05-19
  • [Presentation] MI標準高値は耐糖能異常、脂質異常、高血圧の危険因子である2010

    • Author(s)
      和田輝里子, 他
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      ラヴィール岡山
    • Year and Date
      2010-05-29
  • [Presentation] Fat mass and obesityassociated (FTO)遺伝子多型は肥満と運動量依存性に関連している2010

    • Author(s)
      柄澤繁, 他
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      ラヴィール岡山
    • Year and Date
      2010-05-28
  • [Presentation] Clusterin/apolipoproteinJ遺伝子多型と 2型糖尿病との関連2010

    • Author(s)
      大門真, 他
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
  • [Presentation] 糖尿病発症と関連性を示した Microsomal glutathioneS-transferase 1 (MGST1)遺伝子の疫学的解析2009

    • Author(s)
      諏佐真治, 他
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-05-29
  • [Presentation] Human 8-oxoguanin DNAglycosylase (hOGG1)遺伝子多型は 2型糖尿病と関連している2009

    • Author(s)
      大門真, 他
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-05-24
  • [Presentation] GNB3遺伝子C825T多型は食塩摂取量依存性に2型糖尿病の危険因子となっている2008

    • Author(s)
      大門真, 他
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-05-23
  • [Remarks]

    • URL

      http://minfo.id.yamagata-u.ac.jp/naika3/index.html

URL: 

Published: 2014-08-29  

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