2010 Fiscal Year Final Research Report
Regulatory mechanisms of macrophage differentiation in crosstalk between obesity and inflammation : the application to metabolic syndrome
| Project/Area Number |
20590614
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Kyorin University |
|---|
Principal Investigator |
KIZAKI Takako Kyorin University, 医学部, 教授 (00322446)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHNO Hideki 杏林大学, 医学部, 教授 (00133819)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 炎症反応 / マクロファージ / 肥満 / 生活習慣病 / 運動トレーニング |
|---|
| Research Abstract |
β2-adrenergic receptor (β2AR) suppresses inflammatory responses in macrophages. Toll-like receptor 4 stimulation inhibitsβ2AR expression, resulting in enhanced inflammatory responses. Exercise training down-regulates the low-glade inflammation under high fat diet obesity by ghrelin which is expressed in macrophages.
|
