2010 Fiscal Year Final Research Report
Mechanism for vascular dysfunction caused by visceral fat-derived reactive oxygen species
| Project/Area Number |
20590651
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
SHIMABUKURO Michio University of the Ryukyus, 医学部附属病院, 講師 (60271144)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 内臓肥満症 / 血管内皮機能 / 心筋梗塞 / 活性酸素種 |
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| Research Abstract |
In patients with the metabolic syndrome, vascular dysfunction cause cardiovascular events. We previously reported that visceral fat-derived reactive oxygen species (ROS) underlie onset of the metabolic syndrome. In this study, we found that firs, human umbilical vein endothelium produce ROS by addition of palmitic acid, a saturated free fatty acid ; second, palmitic acid induces complex of anti- and pro-ROS proteins in HUVEC ; third, obese animal did not show any vascular dysfunction if it fed normal fat chow. Collectively, saturated fat can directly produce ROS and related proteins in endothelium, and regulate endothelia function.
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Research Products
(13 results)
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[Journal Article] Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.2009
Author(s)
Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y.
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Journal Title
Cell Metab. 10
Pages: 178-88
Peer Reviewed
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[Journal Article] High prevalence of peripheral arterial disease diagnosed by low ankle-brachial index in Japanese patients with diabetes : The Kyushu Prevention Study for Atherosclerosis.2008
Author(s)
Maeda Y, Inoguchi T, Tsubouchi H, Sawada F, Sasaki S, Fujii M, Saito R, Yanase T, Shimabukuro M, Nawata H, Takayanagi R.
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Journal Title
Diabetes Res Clin Pract 82
Pages: 378-382
Peer Reviewed
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