Mechanism for vascular dysfunction caused by visceral fat-derived reactive oxygen species

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590651
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: University of the Ryukyus
• Principal Investigator: SHIMABUKURO Michio University of the Ryukyus, 医学部附属病院, 講師 (60271144)
• Project Period (FY): 2008 – 2010
• Keywords: 内臓肥満症 / 血管内皮機能 / 心筋梗塞 / 活性酸素種

Research Abstract

In patients with the metabolic syndrome, vascular dysfunction cause cardiovascular events. We previously reported that visceral fat-derived reactive oxygen species (ROS) underlie onset of the metabolic syndrome. In this study, we found that firs, human umbilical vein endothelium produce ROS by addition of palmitic acid, a saturated free fatty acid ; second, palmitic acid induces complex of anti- and pro-ROS proteins in HUVEC ; third, obese animal did not show any vascular dysfunction if it fed normal fat chow. Collectively, saturated fat can directly produce ROS and related proteins in endothelium, and regulate endothelia function.

Research Products

• [Journal Article] Distinct effects of pitavastatin and atorvastatin on lipoprotein subclasses in patients of type 2 diabetes mellitus. (2011)
  • Author(s): Shimabukuro M, Higa M, Tanaka H, Shimabukuro T, Yamakawa K, Masuzaki H
  • Journal Title: Diabetic Med 28 Pages: 856-64
  • Peer Reviewed
• [Journal Article] Impaired glucose tolerance, but not impaired fasting glucose, underlies left ventricular diastolic dysfunction. (2011)
  • Author(s): Shimabukuro M, Higa N, Asahi T, PhD, Yamakawa K, Oshiro Y, Higa M, Masuzaki H.
  • Journal Title: Diabetes Care 34 Pages: 686-690
  • Peer Reviewed
• [Journal Article] Human Catalase Gene is Regulated by Peroxisome Proliferator Activated Receptor-gamma through a Response Element Distinct from That of Mouse. (2010)
  • Author(s): Okuno Y, Matsuda M, Miyata Y, Fukuhara A, Komuro R, Shimabukuro M, Shimomura I.
  • Journal Title: Endocr J. 57 Pages: 303-309
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. (2009)
  • Author(s): Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y.
  • Journal Title: Cell Metab. 10 Pages: 178-88
  • Peer Reviewed
• [Journal Article] Adipose expression of catalase is regulated via a novel remote PPAR γ-responsive region. (2008)
  • Author(s): Okuno Y 、Matsuda M 、Kobayashi H 、Nakamura H 、Suzuki E 、Morita K 、Fukuhara A、Komuro R、Shimabukuro M、 Shimomura I.
  • Journal Title: Biochem Biophys Res Commun 366 Pages: 698-704
  • Peer Reviewed
• [Journal Article] High prevalence of peripheral arterial disease diagnosed by low ankle-brachial index in Japanese patients with diabetes : The Kyushu Prevention Study for Atherosclerosis. (2008)
  • Author(s): Maeda Y, Inoguchi T, Tsubouchi H, Sawada F, Sasaki S, Fujii M, Saito R, Yanase T, Shimabukuro M, Nawata H, Takayanagi R.
  • Journal Title: Diabetes Res Clin Pract 82 Pages: 378-382
  • Peer Reviewed
• [Presentation] Effects of miglitol on fat distribution and insulin sensitivity in subjects with metabolic syndrome. (2010)
  • Author(s): Shimabukuro M, Higa M, Tanaka H, Uezu Y. Masuzaki H.
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100326-20100330
• [Presentation] Effects of brown and white rice diet on visceral adiposity and endothelial function : The BRAVO study. (2010)
  • Author(s): Hasegawa J, Higa M, Tanaka H, Shimabukuro M, Masuzaki H.
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100326-20100330
• [Presentation] Visceral adiposity strongly predicts delayed hyperinsulinemia in obese and non-obese subjects. (2010)
  • Author(s): Shimabukuro M, Higa M, Masuzaki H.
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100326-20100330
• [Presentation] Ectopic fat deposition (EFD), metabolic syndrome, and type 2 diabetes. (2010)
  • Author(s): Shimabukuro M, Masuzaki H.
  • Organizer: ICE 2010 Satellite program, Obesity and Metabolic Syndrome.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-30
• [Presentation] Ectopic fat deposition and lipotoxic disorders. (2010)
  • Author(s): Shimabukuro M, Masuzaki H.
  • Organizer: JES-Sponsored Symposia, 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-28
• [Book] 異所性脂肪《メタボリックシンドロームの新常識》 (2010)
  • Author(s): 島袋充生、益崎裕章
  • Total Pages: 29-38
  • Publisher: 日本医事新報
• [Book] チーム医療レベルアップ糖尿病セミナー(第3巻)ケアネットDVD (2009)
  • Author(s): 田中逸、赤井裕輝、島袋充生、穴澤園子