2010 Fiscal Year Final Research Report
A case-control study of lifestyle and insulin resistance as risk factors for hepatocellular carcinoma
| Project/Area Number |
20590672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Radiation Effects Research Foundation |
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Principal Investigator |
OHISHI Waka Radiation Effects Research Foundation, 広島臨床研究部, 臨床検査科長 (20393423)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Saeko 財団法人 放射線影響研究所, 広島臨床研究部, 部長 (70359454)
COLOGNE John 財団法人 放射線影響研究所, 統計部, 任期付研究員 (50344411)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝炎ウイルス / 肝細胞癌 / 生活習慣 / 炎症 / インスリン抵抗性 / コホート内症例対照研究 / 放射線被曝 |
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| Research Abstract |
We examined impact of hepatitis virus infection, radiation, as well as lifestyle on risk of hepatocellular carcinoma (HCC) and biomarkers contributing to increased risk of HCC, using stored sera from a cohort of atomic bomb survivors. This study showed that radiation exposure contributed to increased risk of HCC, independently of hepatitis B and/or C virus infections, and that alcohol consumption, obesity, and smoking were each associated independently with increased risk of non-B, non-C HCC. Higher IL-6 levels contributed to increased risk of HCC irrespective of hepatitis virus infection.
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Research Products
(27 results)
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[Journal Article] Predictive value of the IL28 polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotype 2a and 2b.2011
Author(s)
Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K.
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Journal Title
J Hepatol 54(3)
Pages: 408-414
Peer Reviewed
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[Journal Article] Common variation of IL 28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.2010
Author(s)
Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K.
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Journal Title
J Hepatol. 53(3)
Pages: 439-443
Peer Reviewed
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[Journal Article] Chayama K.A case of fulminant hepatic failure caused by hepatitis E virus.2008
Author(s)
Tsuge M, Noguchi C, Hiraga N, Mori N, Hiramatsu A, Imamura M, Ohishi W, Arataki K, Aikata H, Kawakami Y, Takahashi S
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Journal Title
Clin J Gastroenterol. 1(2)
Pages: 69-74
Peer Reviewed
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[Journal Article] Prevalence of Adult onset multi-factorial disease among offspring of atomic bomb survivors.2008
Author(s)
Fujiwara S, Suyama A, Cologne JB, Akahoshi M, Yamada M, Suzuki G, Koyama K, Takahashi N, Kasagi F, Grant EJ, Lagade F, Hsu WL, Furukawa K, Ohishi W,Tatsukawa Y, Neriishi K, Takahashi I, Ashizawa K, Hida A, Imaizumi M, Nagano J, Cullings HM, Katayama H, Ross P, Kodama K, Shore RE.
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Journal Title
Radiation Res. 170(4)
Pages: 451-457
Peer Reviewed
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[Journal Article] Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis.
Author(s)
Yoshida K, Ohishi W, Nakashima E, Fujiwara S, Akahoshi M, Kasagi F, Chayama K, Hakoda M, Kyoizumi S, Nakachi K, Hayashi T, Kusunoki Y.
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Journal Title
Peer Reviewed
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