2010 Fiscal Year Final Research Report
Elucidating mechanism of protection of saponins from Ginseng Panax against oxidative stress.
| Project/Area Number |
20590701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Ehime University |
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Principal Investigator |
SUZUKI Yoji Ehime University, 大学院・医学系研究科, 講師 (20226567)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUDA Noriaki 愛媛大学, 大学院・医学系研究科, 教授 (10314329)
OKUBO Nobutaka 愛媛大学, 大学院・医学系研究科, 講師 (10432791)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 老年医学 |
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| Research Abstract |
Circulating erythrocytes are constantly exposed to oxidative stress as a result of the high cellular concentration of oxygen and hemoglobin, which is a source of the reactive oxygen species. Exposure to oxidative stress dramatically alters the function of the erythrocyte membrane, such as elevation of viscosity, decrease of deformability. Saponins (especially ginsenosides Rg2 & Rh1) from Ginseng Panax protect the rheological functions of erythrocytes against oxidative stress by preventing the oxidation of SH-groups in band 3 protein. The glucose metabolism were suggested to participate in mechanism of protections.
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