2010 Fiscal Year Final Research Report
Dynamic status of bacterial products transported by OCTNs or MDR-1 in normal and inflamed intestinal epithelia
| Project/Area Number |
20590734
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
FUJIYA Mikihiro Asahikawa Medical College, 医学部, 准教授 (80322915)
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| Co-Investigator(Kenkyū-buntansha) |
OHTAKE Takaaki 旭川医科大学, 医学部, 講師 (10359490)
MAEMOTO Atsuo 旭川医科大学, 医学部, 客員准教授 (40400113)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 腸内細菌とトランスポーター |
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| Research Abstract |
The mammalian intestines maintain intestinal homeostasis by monitoring the intestinal condition through the recognition of the status of commensal bacteria. However, the mechanisms underlying the host-bacterial interaction are insufficiently understood. The present study proposes novel systems to sense bacterial-derived effecters through epithelial membrane transporters and integrins. This investigation demonstrated that a Lactobacillus brevis SBC88-derived effector was recognized through its binding with epithelial integrins, while a Bacillus subtilis-derived effector, competence and sporulation factor (CSF), was taken up by a membrane transporter, OCTN2. Conversely, the up-taken CSF was partially excreted by MDR-1, but most of the CSF in the cytoplasm was though to have been released by other mechanisms. Taken together, the recognition system for intestinal bacteria appears to be regulated by many molecules, including OCTNs, MDRs and integrins.
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[Journal Article] An unusual elevated lesion of the esophagus.2011
Author(s)
Sawada K, Ikuta K, Itabashi K, Suzuki Y, Mizukami Y, Fujiya M, , Kubo K, Tamura Y, Torimoto Y, Kohgo Y
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Journal Title
Peer Reviewed
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[Journal Article] Collagenous colitis appeared after the 6-year administration of lansoprazole.2010
Author(s)
Sawada K, Fujiya M, Itabashi K, Suzuki Y, Kubo K, Kashima S, Nomura Y, Nata T, Ueno N, Ishikawa C, Inaba Y, Itoh T, Moriichi K, Okamoto K, Ikuta K, Tanabe H, Mizukami Y, Kohgo Y
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Journal Title
Clin J Gastorol 3
Pages: 18-21
Peer Reviewed
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[Journal Article] Transnasal ultrathin endoscopy for placement of a long intestinal tube in patients with intestinal obstruction.2008
Author(s)
Sato R, Watari J, Tanabe H, Fujiya M, Ueno N, Konno Y, Ishikawa C, Ito T, Moriichi K, Okamoto K, Maemoto A, Chisaka K, Kitano Y, Matsumoto K, Ashida T, Kono T, Kohgo Y
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Journal Title
Gastrointest Endosc 67(6)
Pages: 953-957
Peer Reviewed
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[Presentation] Competence and Sporulation Factor Derived From Bacillus Subtilis Improves Epithelial Cell Injury in Intestinal Inflammation via Immunomodulation and Cytoprotection.2010
Author(s)
Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y
Place of Presentation
New Orleans
Year and Date
2010-05-05
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[Presentation] Heat-Killed Body of Lactobacillus brevis SBC8803 Contributes to Maintain Intestinal Homeostasis and Improve Intestinal Injury in a Murine Model of Colitis.2010
Author(s)
Ueno N, Fujiya M, Segawa S, Nata T, Inaba Y, Moriichi K, Tanabe H, Mizukami Y, Kobayashi N, Ito K, Kohgo Y
Organizer
DDW 2010 (AGA)
Place of Presentation
New Orleans
Year and Date
2010-05-04
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[Presentation] Autofluorescence Imaging Can Evaluate the Dysplastic Grade of a Colonic Neoplasm by Detecting the Nucleus Enlargement of Tumor Cells.2010
Author(s)
Moriichi K, Fujiya M, Sato R, Nata T, Nomura Y, Ueno N, Ishikawa C, Inaba Y, Ito T, Okamoto K, Tanabe H, Watari J, Saitoh Y, Kohgo Y
Place of Presentation
New Orleans
Year and Date
2010-05-03
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[Patent(Industrial Property Rights)]2010
Inventor(s)
高後裕,藤谷幹浩,上野伸展,瀬川修一,小林直之
Industrial Property Rights Holder
国立大学法人旭川医科大学,サッポロビール株式会社
Patent Publication Number
特許権,特開2010-083881
Acquisition Date
2010-04-15
