2010 Fiscal Year Final Research Report
Elucidation of the immunoresponse by direct stimulation of fatty acid in Crohn disease
| Project/Area Number |
20590739
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TSUJIKAWA Tomoyuki Shiga University of Medical Science, 医学部, 教授 (80273407)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIYAMA Yoshihide 滋賀医科大学, 医学部, 教授 (70111896)
ANDOH Akira 滋賀医科大学, 大学院・医学研究科, 教授 (90252395)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脂肪乳剤 / クローン病 / TNF-α / RT-PCR |
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| Research Abstract |
To make clear that a high-fat food intake involves Crohn disease aggravation directly, I scattered fat into the ileum end during small intestinal endoscopy and compared mucosal cytokine (TNF-α) levels in between pre and post fat stimulation. The levels of TNF-α mRNA in many cases decreased after the fat stimulation, contrary to my expectation. Therefore, it was suggested that the immunoresponse in the mucosa control possibility the local inflammation in Crohn disease.
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[Journal Article] Novel single-balloon enteroscopy for diagnosis and treatment of the small intestine : preliminary experiences.2008
Author(s)
Tsujikawa T, Saitoh Y, Andoh A, Imaeda H, Hata K, Minematsu H, Senoh K,Hayafuji K, Ogawa A, Nakahara T, Sasaki M, Fujiyama Y.
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Journal Title
Peer Reviewed
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[Journal Article] [Case report : periodical infliximab administration enabled closure of colostomy in fistulating perianal Crohn's disease].2008
Author(s)
Tsujikawa T, Imaeda H, Kobayashi Y, Oosaki R, Sonoda A, Senou K, Hayafuji K,Minematsu H, Ogawa A, Nakahara T, Hata K, Andoh A, Sasaki M, Saito Y, Fujiyama Y.
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Journal Title
Nippon Shokakibyo Gakkai Zasshi. 105(6)
Pages: 825-829
Peer Reviewed
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