2010 Fiscal Year Final Research Report
Development of a biomarker for inflammatory bowel disease by plasma amino acids profile.
| Project/Area Number |
20590749
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Keywords | 炎症性腸疾患 / アミノ酸 / ヒスチジン / 炎症性サイトカイン / マクロファージ / アミノインデックス[○!R] / メタボローム |
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| Research Abstract |
Amino acids in Elental[○!R] directly suppress intestinal inflammation in IL-10 transfer colitis models. Especially, L-histidine suppressed NFkB activation and significantly inhibited the production of pro-inflammatory cytokines by macrophages. In human IBD, plasma amino acids profiles were dramatically changed. Plasma histidine concentration was decreased in active IBD patients and showed inverted correlation with serum CRP. Furthermore, the computer analysis of plasma amino acids profiles developed the AminoIndex[○!R] that is a parameter for diagnosis and assessment of disease activity in IBD.
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[Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages.2011
Author(s)
Naruse H, Hisamatsu T, Yamauchi Y, Chang JE, Matsuoka K, Kitazume MT, Arai K, Ando S, Kanai T, Kamada N, Hibi T.
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Journal Title
Clin Exp Immunol. 164(1)
Pages: 137-44
Peer Reviewed
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[Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.2010
Author(s)
Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T.
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Journal Title
Gastroenterology. 139(3)
Pages: 882-92
Peer Reviewed
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[Journal Article] Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10-Producing Regulatory Macrophage Subset.2010
Author(s)
Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T.
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Journal Title
J Immunol. 184(5)
Pages: 2671-6
Peer Reviewed
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[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.2010
Author(s)
Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
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Journal Title
Inflamm Bowel Dis. 16(4)
Pages: 568-75
Peer Reviewed
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[Journal Article] Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen presenting ability.2009
Author(s)
Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Kitazume M, Takayama T, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
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Journal Title
J Immunol. 183(3)
Pages: 1724-31
Peer Reviewed
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[Journal Article] Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production from Macrophages.2009
Author(s)
Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
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Journal Title
Gastroenterology. 136(2)
Pages: 564-74
Peer Reviewed
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