2011 Fiscal Year Final Research Report
Molecular mechanism of overlap between chronic liver disease and iron metabolism abnormality
| Project/Area Number |
20590754
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKUTA Katsuya 旭川医科大学, 医学部, 講師 (00396376)
SASAKI Katsunori 旭川医科大学, 医学部, 特任准教授 (60336394)
SATOU Kazuya 旭川医科大学, 医学部, 講師 (50360988)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 非アルコール性脂肪性肝疾患 / アルコール性肝障害 / トランスフェリン受容体 / ヘプシジン / 鉄トランスポーター |
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| Research Abstract |
Excess iron is frequently accumulated in chronic liver diseases. The pathogenesis and iron metabolism abnormality are overlapped, which may be progressed by the interaction. Non-alcoholic fatty liver disease (NAFLD) also frequently merges with secondary hepatic iron accumulation, which contributes to the development of oxidative stress, liver cell damage, fibrosis and carcinogenesis. In this study, we investigated the expression of iron-related molecules in liver and duodenum tissue in mice fatty liver model and human hepatocellular in vitro model. Obesity and high-fat diet up-regulate TfR1 expression and down-regulate Hepc expression in the liver. Furthermore they up-regulate the iron transporter expressions in the duodenum.
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[Presentation] Alcohol-loading and obesity regulate the expression of transferrin receptor 1 and hepcidin in mice liver2010
Author(s)
Ohtake T, Ikuta K, Hasebe S, Nakajima S, Sawada K, Abe M, Hosoki T, Suzuki Y, Sasaki K, Torimoto Y, Kohgo Y.
Organizer
Falk Workshop
Place of Presentation
Freiburg, Germany.
Year and Date
20101005-06
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[Presentation] Metabolic steatosis and alcohol-loading regulate the expression of transferrin receptor 1 and hepcidin in mice liver2009
Author(s)
Ohtake T, Ikuta K, Sawada K, Abe M, Hosoki T, Miyoshi S, Suzuki Y, Sasaki K, Torimoto Y, Kohgo Y
Organizer
2009 International BioIron Society Meeting
Place of Presentation
Porto, Portugal
Year and Date
20090607-11
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