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2010 Fiscal Year Final Research Report

Mechanism of Neutralization using Infectious Hepatitis C Chimeric Viruses

Research Project

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Project/Area Number 20590757
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionYamagata University

Principal Investigator

WATANABE Hisayoshi  山形大学, 医学部, 講師 (00332536)

Co-Investigator(Kenkyū-buntansha) SHAO Li  山形大学, 医学部, 助教 (80344787)
Co-Investigator(Renkei-kenkyūsha) ISHII Rika  山形大学, 医学部, 助教 (60466612)
Project Period (FY) 2008 – 2010
KeywordsHCV / ワクチン / 中和抗体
Research Abstract

Neutralizing antibody (NAb) is thought to play an important role in HCV infection. Detailed analysis of HCV NAb titer using newly developed cell culture system was performed. The level of NAb was low in the early phase of infection, suggested the cytotoxic immune response was a major role. While, the titer of NAb was decreased because of the sequence of neutralizing epitope was changed during the chronic phase. These results suggest the mechanism why HCV can be infected persistently.

  • Research Products

    (28 results)

All 2011 2010 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (9 results) Book (7 results)

  • [Journal Article] (99m) Tc-GSA SPECT analysis was clinically useful to evaluate the effect of interferon in a patient with interferon non-responsive chronic hepatitis C2011

    • Author(s)
      Ishii R, Togashi H, Iwaba A, Sato C, Haga H, Sanjo M, Okumoto K, Nishise Y, Ito JI, Watanabe H, Saito K, Okada A, Takahashi K, Saito T, Kawata S
    • Journal Title

      Ann Nucl Med

      Pages: 520-523

    • Peer Reviewed
  • [Journal Article] Potential therapeutic application of intravenous autologous bone marrow infusion in patients with alcoholic liver cirrhosis2011

    • Author(s)
      Saito T, Okumoto K, Haga H, Nishise Y, Ishii R, Sato C, Watanabe H, Okada A, Ikeda M, Togashi H, Ishikawa T, Terai S, Sakaida I, Kawata S
    • Journal Title

      Stem Cells Dev

      Pages: 1503-1510

    • Peer Reviewed
  • [Journal Article] Sequence heterogeneity of NS5A and core proteins of hepatitis C virus and virological responses to pegylated-interferon/ribavirin combination therapy2011

    • Author(s)
      El-Shamy A, Shoji I, Saito T, Watanabe H, Ide YH, Deng L, Kawata S, Hotta H
    • Journal Title

      Microbiol Immunol

      Pages: 418-426

    • Peer Reviewed
  • [Journal Article] Serum metabolomics reveals γ-glutamyl dispeptides as biomarkers for discrimination among different forms of liver disease2011

    • Author(s)
      Soga T, Sugimoto M, Honma M, Mori M, Igarashi K, Kashikura K, Ikeda S, Hirayama A, Yamamoto T, Yoshida H, Otsuka M, Tsuji S, Yatomi Y, Sakuragawa T, Watanabe H, Nihei K, Saito T, Kawata S, Suzuki H, Tomita M, Suematsu M
    • Journal Title

      J Hepatol

      Pages: 896-965

    • Peer Reviewed
  • [Journal Article] Enhanced expression of fibroblast growth factor 2 in bone marrow cells and its potential role in the differentiation of hepatic epithelial stem-like cells into the hepatocyte lineage2010

    • Author(s)
      Haga H, Saito T, Okumoto K, Ugajin S, Sato C, Ishii R, Nishise Y, Ito J, Watanabe H, Saito K, Togashi H, Kawata S
    • Journal Title

      Cell Tissue Res

      Volume: 343 Pages: 371-378

    • Peer Reviewed
  • [Journal Article] Secondary structure of the amino-terminal region of HCV NS3 and virological response to pegylated interferon plus ribavirin therapy for chronic hepatitis C2010

    • Author(s)
      Sanjo M, Saito T, Nishise Y, Haga H, Okumoto K, Ito J, Watanabe H, Saito K, Togashi H, Fukuda K, Imai Y, El Shamy A, Deng L, Shoji I, Hotta H, Kawata S
    • Journal Title

      J Med Virol

      Volume: 82 Pages: 1364-1370

    • Peer Reviewed
  • [Journal Article] Relationship between alcohol consumption and serum adiponection levels : the Takahata study-a cross-sectional study of a healthy Japanese population2010

    • Author(s)
      Nishise Y, Saito T, Makino N, Okumoto K, Ito JI, Watanabe H, Saito K, Togashi H, Ikeda C, Kubota I, Daimon M, Kato T, Fukao A, Kawata S
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 95 Pages: 3828-3835

    • Peer Reviewed
  • [Journal Article] Expression of the RNA-binding protein Musashi1 in adult liver stem-like cells2010

    • Author(s)
      Hattori E, Shu HJ, Saito T, Okumoto K, Haga H, Yokozawa J, Ito J, Watanabe H, Saito K, Togashi H, Kawata S
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 432-437

    • Peer Reviewed
  • [Journal Article] Clearance of hepatitis C in chimpanzees is associated with intrahepatic T-cell perforin expression during late acute phase2010

    • Author(s)
      Watanabe H, Wells F, Major ME
    • Journal Title

      J Viral Hepatitis

      Volume: 17 Pages: 245-253

    • Peer Reviewed
  • [Journal Article] Impact of metabolic syndrome on elevated serum alanine aminotransferase levels in the Japanese population2009

    • Author(s)
      Saito T, Nishise Y, Makino N, Haga H, Ishii R, Okumoto K, Ito JI, Watanabe H, Saito K, Takeda H, Togashi H, Kubota I, Daimon M, Kato T, Kawata S
    • Journal Title

      Metabolism

      Volume: 58 Pages: 1067-1075

    • Peer Reviewed
  • [Journal Article] Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity2009

    • Author(s)
      Zhang P, Zhong L, Struble EB, Watanabe H, Kachko A, Mihalik K, Virata-Theimer ML, Alter HJ, Feinstone S, Major ME
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 106(18) Pages: 7537-7541

    • Peer Reviewed
  • [Journal Article] T-cell vaccines that elicit effective immune responses against HCV in chimpanzees may create greater immune pressure for viral mutation2009

    • Author(s)
      Zubkova I, Choi YH, Chang E, Pirollo K, Uern T, Watanabe H, Wells F, Kachko A, Krawczynski K, Major ME
    • Journal Title

      Vaccine

      Volume: 27 Pages: 2594-2602

    • Peer Reviewed
  • [Presentation] Incidence of hepatocellular carcinoma after achieving sustained virological response to interferon therapy for chronic hepatitis C2010

    • Author(s)
      Watanabe H, Saito T, Ishii R, Sato C, Haga H, Sanjo M, Okumoto K, Nishise Y, Ito J, Saito K, Kawata S
    • Organizer
      The 61th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston,USA
    • Year and Date
      2010-11-03
  • [Presentation] Clearance of hepatitis C virus in chimpanzees is associated with intrahepatic perforin expression during the late acute phase2010

    • Author(s)
      Watanabe H, Wells F, Saito T, Sato C, Ishii R, Haga H, Sanjo M, Okumoto K, Nishise Y, Ito J, Saito K, Kawata S, Major ME
    • Organizer
      18th United European Gastroenterology Week
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-10-26
  • [Presentation] B型肝炎ジェノタイプB型高浸淫地域における急性B型肝炎の実態2010

    • Author(s)
      渡辺久剛, 斎藤貴史, 西瀬雄子, 佐藤智佳子, 石井里佳, 芳賀弘明, 三條麻衣, 奥本和夫, 伊藤純一, 斉藤孝治, 冨樫整, 新澤陽英, 河田純男
    • Organizer
      第14回日本肝臓学会大会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2010-10-13
  • [Presentation] HCVコホート研究による持続感染者の自然経過2010

    • Author(s)
      渡辺久剛, 斎藤貴史, 西瀬雄子, 邵力, 佐藤智佳子, 石井里佳, 芳賀弘明, 三條麻衣, 奥本和夫, 伊藤純一, 斉藤孝治, 石橋正道, 冨樫整, 新澤陽英, 河田純男
    • Organizer
      第46回日本肝臓学会総会サテライトシンポジウム「HCV感染のnatural courseを探る:わが国におけるコホート研究」
    • Place of Presentation
      山形市山形テルサ
    • Year and Date
      2010-05-29
  • [Presentation] HCVコホートにおけるウイルス自然治癒および肝発癌の検討2010

    • Author(s)
      渡辺久剛, 斎藤貴史, 西瀬雄子, 佐藤智佳子, 石井里佳, 芳賀弘明, 三條麻衣, 奥本和夫, 伊藤純一, 斉藤孝治, 冨樫整, 新澤陽英, 河田純男
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市ホテルメトロポリタン山形
    • Year and Date
      2010-05-27
  • [Presentation] Natural Clearance of Hepatitis C Virus (HCV) RNA in Chronic HCV Carriers : A Long-Term Cohort Study in an Endemic Area of HCV Infection in Japan2009

    • Author(s)
      Watanabe H, Saito T, Nishise Y, Sasaki Y, Sato C, Ishii R, Haga H, Sanjo M, Okumoto K, Ito J, Saito K, Shinzawa H, Kawata S
    • Organizer
      60th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-11-03
  • [Presentation] Real-time PCR法を用いたHCV持続感染者におけるウイルス自然陰性化の検討2009

    • Author(s)
      渡辺久剛, 斎藤貴史, 西瀬雄子, 佐藤智佳子, 宇賀神智, 石井里佳, 芳賀弘明, 三條麻衣, 奥本和夫, 伊藤純一, 斉藤孝治, 冨樫整, 新澤陽英, 河田純男
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸市神戸ポートピアホテル
    • Year and Date
      2009-06-04
  • [Presentation] A Long-Term Population-Based Cohort Study in an Endemic Area of Hepatitis C Virus in Japan : Spontaneous Elimination of Serum HCV RNA Detected by the Real-Time PCR System2009

    • Author(s)
      Watanabe H, Saito T, Shao L, Nishise Y, Ishii R, Haga H, Okumoto K, Ito J, Saito K, Shinzawa H, Kawata S
    • Organizer
      13th International Symposium on Viral Hepatitis and Liver Disease
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2009-03-18
  • [Presentation] 1a/2a chimera HCV培養細胞感染系を用いたHCV中和抗体レベルの解析2008

    • Author(s)
      渡辺久剛, 斉藤貴史, 河田純男
    • Organizer
      シンポジウム「C型ウイルス肝炎治療の新潮流」第44回日本肝臓学会総会
    • Place of Presentation
      松山市愛媛県県民文化会館
    • Year and Date
      2008-06-05
  • [Book] HCVコホート研究による持続感染者の自然経過.HCV感染のnatural courseを探る:わが国におけるコホート研究(河田純男監修、佐田通夫・新沢陽英・斎藤貴史編)2011

    • Author(s)
      渡辺久剛, 斎藤貴史, 西瀬雄子, 邵力, 佐藤智佳子, 石井里佳, 芳賀弘明, 奥本和夫, 斎藤孝治, 冨樫整, 新沢陽英, 河田純男
    • Total Pages
      45-50
    • Publisher
      山形大学出版
  • [Book] 分子標的薬治療における消化器症状対策.分子標的薬トータルマネージメントYURCCパッケージver.1.2(冨田善彦編)2010

    • Author(s)
      渡辺久剛
    • Total Pages
      23-27
    • Publisher
      リッチヒルメディカル
  • [Book] 慢性肝炎.ハリソン内科学第3版(福井次矢、黒川清編)2009

    • Author(s)
      渡辺久剛, 河田純男
    • Total Pages
      2022-2037
    • Publisher
      メディカル・サイエンス・インターナショナル
  • [Book] HCVキャリアからのHCV RNA自然消失はあるのか?肝臓病診療こんなときどうするQ & A(河田純男、佐々木裕編)2009

    • Author(s)
      渡辺久剛, 河田純男
    • Total Pages
      47-51
    • Publisher
      中外医学社
  • [Book] PegIFN+リバビリン療法の治療効果はウイルス学的にどこまで予測できるか?肝臓病診療こんなときどうするQ & A(河田純男、佐々木裕編)2009

    • Author(s)
      齋藤貴史, 渡辺久剛, 河田純男
    • Total Pages
      364-367
    • Publisher
      中外医学社
  • [Book] 当科における肝硬変の成因別実態.肝硬変の成因別実態(青柳豊、他編)2008

    • Author(s)
      宇賀神智, 奥本和夫, 斎藤貴史, 佐藤智佳子, 芳賀弘明, 石井里佳, 鈴木明彦, 三條麻衣, 西瀬雄子, 伊藤純一, 菅原一彦, 渡辺久剛, 斎藤孝治, 冨樫整, 河田純男
    • Total Pages
      77-80
    • Publisher
      中外医学社
  • [Book] 肝硬変.肝臓病のすべて(与芝真彰編)2008

    • Author(s)
      渡辺久剛, 河田純男
    • Total Pages
      69-74
    • Publisher
      日本評論社

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Published: 2013-07-31  

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