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2010 Fiscal Year Final Research Report

A comprehensive study of recombinant hepatitis B virus genotype

Research Project

  • PDF
Project/Area Number 20590788
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionNagoya City University

Principal Investigator

SUGAUCHI Fuminaka  Nagoya City University, 大学院・医学研究科, 研究員 (20405161)

Co-Investigator(Kenkyū-buntansha) MIZOKAMI Masashi  名古屋市立大学, 大学院・医学研究科, 客員教授 (40166038)
Project Period (FY) 2008 – 2010
KeywordsB型肝炎ウイルス / 遺伝子型 / 肝癌 / ウイルス変異
Research Abstract

We investigated recombinant HBV genotype (r-HBV)using 807 full-genome sequences of HBV retrieved from DNA Data Bank. Twenty eight r-HBV were shown, 12 for A/D, 2 for A/C, 2 for/AE, 1 for A/G, 1 for A/B/C, 2 for B/C, 2 for C/D, 1 for C/F, 1 for C/G and 2 for U/G. Junction of r-HBV was more common at C terminus of S gene and core region.

  • Research Products

    (12 results)

All 2011 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Virological Characteristics of hepatitis B virus on reactivation of hepatitis B in individuals with resolved infection.2011

    • Author(s)
      Sugauchi F, Mizokami M.
    • Journal Title

      J Med Virol. 83

      Pages: 412-418

    • Peer Reviewed
  • [Journal Article] Distribution of Hepatitis B Virus Genotypes among Patients with Chronic Infection in Japan Shifting toward an Increase of Genotype A.2009

    • Author(s)
      Matsuura K, Sugauchi F, Mizokami M.
    • Journal Title

      J Clin Microbiol. 47

      Pages: 1476-1483

    • Peer Reviewed
  • [Presentation] In vivo model using uPA/SCID mice with human hepatocytes to study cross-genotype protection of HBV and a roleof HBs antigen mutation in immunity escape.2010

    • Author(s)
      菅内文中
    • Organizer
      The 61^<st> annual meeting of the AASLD.
    • Place of Presentation
      The Hynes Conventi on Center (Boston USA.)
    • Year and Date
      20101030-20101103
  • [Presentation] B型肝炎の母子および水平感染の実態とワクチン戦略:ヒト肝細胞キメラマウスにおけるB型肝炎ウイルス感染防御の試み2010

    • Author(s)
      菅内文中
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      ホテルメトロポリタン山形(山形市)
    • Year and Date
      20100527-20100528
  • [Presentation] Identification of genetic variants associated with chronic hepatitis B or C in a genome-wide association.2009

    • Author(s)
      Matuura K. Sugauhch F.
    • Organizer
      The 8^<th> JSH Single Topic Conference "HBV Now In Asia".
    • Place of Presentation
      National Center for Global Health and Medicine (Tokyo Japan)
    • Year and Date
      20091121-20091122
  • [Presentation] A genome-wide association study identifies genetic variants in the HLA-DP associated with chronic hepatitis B.2009

    • Author(s)
      Matsuura K. Sugauhch F.
    • Organizer
      The 60^<th> American Association for the Study of Liver Disease (AASLD).
    • Place of Presentation
      The Hynes Conv ention Center (Boston USA)
    • Year and Date
      20091030-20091103
  • [Presentation] Clinical significance of a novel high-sensitivity hepatitis B surface antigen immunoassay in patients with hepatitis B virus infection.2009

    • Author(s)
      菅内文中
    • Organizer
      The 60^<th> American Association for the Study of Liver Disease (AASLD).
    • Place of Presentation
      The Hynes Convention Center (Boston USA)
    • Year and Date
      20091030-20091103
  • [Presentation] B型慢性肝炎難治例への対策B型肝炎に対するAdefovir、Entecavirの治療成績と多剤耐性HBV変異株に対するTenofovirの有効性(シンポジウム10:B型慢性肝炎難治例への対策)2009

    • Author(s)
      菅内文中
    • Organizer
      第13回日本肝臓学会大会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      20091014-20091016
  • [Presentation] Influences of hepatitis B virus genotype and precore mutations on reactivation of occult hepatitis B in patients with hematological malignancy.2008

    • Author(s)
      菅内文中
    • Organizer
      The 59th American Association for the Study of Liver Disease (AASLD).
    • Place of Presentation
      Moscone West Convention Center (San Francisco USA)
    • Year and Date
      20081031-20081104
  • [Presentation] 造血器悪性腫瘍治療後のHBV再活性化に対する方策(シンポジウム)2008

    • Author(s)
      菅内文中
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      グランドプリンスホテル新高輪他(東京都)
    • Year and Date
      20081001-20081004
  • [Presentation] B型ウイルス肝炎の治療B型慢性肝炎に対するエンテカビル長期投与の有用性(ワークショップ)2008

    • Author(s)
      田中靖人.菅内文中
    • Organizer
      第44日本肝臓学会総会
    • Place of Presentation
      愛媛県県民文化会館(松山市)
    • Year and Date
      20080605-20080606
  • [Presentation] B型慢性肝疾患の治療戦略エンテカビル長期投与による治療効果及び耐性変異出現パターン2008

    • Author(s)
      田中靖人.菅内文中
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡サンパレスホテル&ホール(福岡市)
    • Year and Date
      20080508-20080510

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Published: 2012-01-26   Modified: 2016-04-21  

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