2010 Fiscal Year Final Research Report
New therapy for diastolic heart failure from the standpoint of insulin resistance
| Project/Area Number |
20590826
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tottori University |
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Principal Investigator |
OGINO Kazuhide Tottori University, 医学部附属病院, 准教授 (70294311)
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| Co-Investigator(Kenkyū-buntansha) |
HISATOME Ichiro 鳥取大学, 医学(系)研究科(研究院), 教授 (60211504)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖代謝異常 / 拡張不全 / インスリン抵抗性 |
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| Research Abstract |
[Aim] (1) The effects of pioglitazone (PIO), benzbromarone (BENZ) and losartan (LOS) in CHF with insulin resistance (IR), (2) the effects of exercise and PIO in CHF mouse.
[Results] PIO, BENZ and LOS improved inflammatory cytokines and IR in CHF. Serum uric acid level and inflammatory cytokines were correlated with IR. In CHF mouse, both PIO and exercise improved IR and cardiac function with the reduction of inflammatory cytokines and matrix metalloproteinases (MMPs).
[Conclusion] There was relationship between IR and cardiac function in CHF, which may be mediated via inflammatory cytokines and MMPs.
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[Journal Article] Addition of losartan to angiotensin- converting enzyme inhibitors improves insulin resistance in patients with chronic heart failure treated without β-blockers.2010
Author(s)
Ogino K, Kato M, Furuse Y, Kinugasa Y, Kaetsu Y, Mizuta E, Sugihara S, Ishida K, Yanagihara K, Hisatome I, Shigemasa C.
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Journal Title
Circ J. 74
Pages: 2346-2352
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[Journal Article] Uric acid-lowering treatment with benzbromarone in patients with heart failure : a doubleblind placebo-controlled crossover preliminary study.2010
Author(s)
Ogino K, Kato M, Furuse Y, Kinugasa Y, Ishida K, Osaki S, Kinugawa T, Igawa O, Hisatome I, Shigemasa C, Anker SD, Doehner W.
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Journal Title
Circ Heart Fail. Jan;3:
Pages: 73-81
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