2010 Fiscal Year Final Research Report
Translational research concerning diagnosis, management, and treatment in cardiovascular disease using vasoactive peptide
| Project/Area Number |
20590837
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
NISHIKIMI Toshio Dokkyo Medical University, 医学研究科, 准教授 (80291946)
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| Co-Investigator(Renkei-kenkyūsha) |
MINAMINO Naoto 国立循環器病センター, 研究所や栗部, 部長 (50124839)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 臨床心血管病態学 / ナトリウム利尿ペプチド / 心不全 / BNP / ANP / アドレノメデュリン / 脂肪細胞 / Rho-kinase阻害薬 / 腎疾患 |
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| Research Abstract |
We investigated the pathophysiological significance of B-type natriuretic peptide (BNP), adrenomedullin, and Rho-kinsae inhibitor. We found that current BNP assay kit measures not only BNP-32, but also proBNP-108 and that measurement of both molecular forms provides more useful information in heart failure. We showed that AM mRNA is highly expressed in adipose tissue and that AM plays a role in lipid and glucose metabolism. Furthermore, we showed that Rho-kinase is activated in the kidney in renal disease and that Rho-kinase inhibitor is effective in treatment for various renal disease models via many mechanisms including inhibition of oxidative stress, inflammation, collagen production, etc.
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Research Products
(33 results)
